baker414
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Posts: 3
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q1)6. A biosynthetic error in reading the genetic code gives rise to an enzyme that folds in an abnormal manner. Which of the following is most likely to happen to this enzyme?
A ) Denaturation and refolding
B ) Faster degradation
C ) Inactivation by phosphorylation
D ) Transportation out of the cell via the Golgi complex
q2)9. The splicing of primary gene transcripts in eukaryotic cells is most likely to have which of the following effects?
A ) Decreased stability of mRNAs
B ) Generation of hybrid (chimeric) mRNAs
C ) Increased repertoire of gene products
D ) Increased size of mRNAs
E ) Rearrangement of cellular genome
Q3)
A 5-day-old female newborn who is breast-fed is brought to the emergency department because of a 1-day history of poor feeding, vomiting, and lethargy. Physical examination shows decreased responsiveness, hypotonia, and dehydration. There is a caramel-like odor in the diaper. Serum studies show a decreased glucose concentration, ketones, and metabolic acidosis. Metabolic studies of leukocytes show no conversion of [14C] leucine to 14CO2. An increased plasma concentration of which of the following substances is most likely in this patient?
A ) Alanine
B ) Isovaleric acid
C ) Methylmalonic acid
D ) Phenylalanine
E ) Propionic acid
F ) Valine
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| hottie99
Forum Elite
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Posts: 427
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q3 is valine, that pt has maple syrup disease, so they have too much LIV (leucine, isoleucine, valine) that they can't break down since they are lacking alpha ketoacid dehydrogenase
not sure on others 
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| Smash82
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q1 is B) Faster degradation - misfolded proteins are ubiquitinated and degraded by proteosomes
q2 is B) generation of hybrid mRNAs - since alternative splicing can produce a variety of mRNAs to form different proteins
q3 is F) Valine as per Hottie 99's explanation
Hope this is right...let us know wat the correct answers are
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| taipei817
Forum Newbie
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1. B ubiquitination
2. C increase repetoir via alternative splicing
3. E propionic acid
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| hottie99
Forum Elite
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Posts: 427
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taipei, i may not know anything about the first 2 questions, but i know for sure it's valine, b/c its maple syrup disease, no??
as for the other two, could u explain why u feel those answers versus the other person?? thx, i just dont understand molecular stuff 
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| taipei817
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yep, i agree its maple syrup now, thanks.
for the other two, i dont have any theory behind it, but those are observations that a pre-mRNA is sliced different ways to produce different mRNA that produces different protein. thats why although the human genome is not much bigger than c elegans, we do have the potential to make a lot more different kind of proteins.
as for ubiquitination, i just know that misfolded proteins are ubiquinated and degraded by proteosomes inside the cell.
lets see what the answer is.
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