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ETC vs Ox. phosphorylataion
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Author4 Posts
  #1

How do differentiate an inhibitor of ETC from an uncoupler of oxidative phosphorylation??


  #2

What I think...
Inhibitors bind to components of ETC Uncouplers increase permeability of membrane
block e transport increase e transport
decrease proton gradient suppress proton gradient
decrease ATP s-s suppress ATP s-s


  #3

I did try to post the tab on my prev. post...looks confusing...here you go again
Inhibitors: bind to components of ETC, block e transport, decrease proton gradient, decrease ATP s-s.
Uncouplers: increase membrane permeability, increase e transport, suppress proton gradient, suppress ATP s-s.
So, the difference in e transport. Does it make sence?


  #4

Uncouplers prevent proton pumping, therefore reduced PMF and reduced ATP synthesis.

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