hottie99
Forum Elite
Topics: 30
Posts: 552
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im not proving anything, and nor did i direct anything ur direction. we were having a productive discussion as u can read above, my comments are directed to ppl who feel the need to be rude, which is worthless since we're all asking quesitons to clarify thoughts not to prove anything to anyone.. good luc!
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| baryar
Forum Newbie
Topics: 6
Posts: 26
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thanx to aal of u.i learned alot thru the discussion.......so,THIS IS A CASE OF APLASTIC ANEMIA.
for those who think it was just meant to b a teaser, well,i never had this intention.i respect knowledge and for me the best way of getting knowledge is to learn by counter-discussions.
for those who think that EPO doesnt effect platelet synthesis........i have a link ( it not to open a new debate, its just knowledge sharing ).....
http://bloodjournal.hematologylibrary.org/cgi/con...
and ofcourse many more similar studies.
once again,thnx to aal of u..and in any case,this question may not b much relevant to ur exam questions..it was just a discussion.
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| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
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baryar wrote:thanx to aal of u.i learned alot thru the discussion.......so,THIS IS A CASE OF APLASTIC ANEMIA. for those who think it was just meant to b a teaser, well,i never had this intention.i respect knowledge and for me the best way of getting knowledge is to learn by counter-discussions. for those who think that EPO doesnt effect platelet synthesis........i have a link ( it not to open a new debate, its just knowledge sharing )..... http://bloodjournal.hematologylibrary.org/cgi/con... and ofcourse many more similar studies. once again,thnx to aal of u..and in any case,this question may not b much relevant to ur exam questions..it was just a discussion.
We do know the relationship of EPO having an effect on platelets but the bone marrow and the lymphocyte count is not explained by the EPO def. scenario. EPO also doesnt explain the rest of the clinical picture which includes the Retic count. Now if the corrected retic count was below 3% the diagonsis of Aplastic Anemia fits and if not then labs are to be repeated. Another thing is that with EPO def you will see Normocytic Anemia instead of Microcytic Anemia And the lab report didnt have the morphological picture of the RBCs ( burr cells are a classic sign of EPO related anemia).
Anyways it would really productive if by any chance you could go and have look at that particular patient and see what actually happened.
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| bioguy
Forum Guru
Topics: 40
Posts: 748
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baryar wrote:thanx to aal of u.i learned alot thru the discussion.......so,THIS IS A CASE OF APLASTIC ANEMIA. for those who think it was just meant to b a teaser, well,i never had this intention.i respect knowledge and for me the best way of getting knowledge is to learn by counter-discussions. for those who think that EPO doesnt effect platelet synthesis........i have a link ( it not to open a new debate, its just knowledge sharing )..... http://bloodjournal.hematologylibrary.org/cgi/con... and ofcourse many more similar studies. once again,thnx to aal of u..and in any case,this question may not b much relevant to ur exam questions..it was just a discussion.
Ok, brother!!! The significant finding in the above article was to see if EPO stimulated the reactivity of platelets. They also found about 15% increase in platelet count, but that was also seen in placebo group - after phlebotomies of course. Lets say EPO does stimulate thrombopoiesis.
Now the argument here is a bit complex. Please try to follow.
Point #1: TPO is the main factor that drives Thrombopoiesis.
Point #2: EPO stimulates Thrombopoiesis. (lets say I agree with this)
Now...
In EPO deficiency, do you think there won't be any TPO to drive the Thrombopoiesis???
In other words, do you think ISOLATED EPO DEFICIENCY can cause decreased platelet counts?
Do you understand the issue here? So if you can find a study in which they find
reduced EPO levels,
normal TPO levels and
reduced platelet count
- THAT WILL NAIL YOUR POINT!!! 
Edited by bioguy on 04/08/08 - 05:41 PM
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| bioguy
Forum Guru
Topics: 40
Posts: 748
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For example, look at this paper -
http://www3.interscience.wiley.com/cgi-bin/abstra...
in this case, there is decreased EPO levels but normal platelet count and wbc count.
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| uppi
Forum Newbie
Topics: 0
Posts: 2
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Also, I dont know if anyone mentioned this, and im not 100% sure, but in regards to the Normal Lympocyte Count regarding the Aplastic Anemia Case. Aplastic Anemia is Hypoplasia of the BONE MARROW, and it is my understanding that the lympoid series does not mature and develop in the bone marrow. Can someone confirm this?
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| bioguy
Forum Guru
Topics: 40
Posts: 748
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yeah, i had a question about this.
the lymphoid series, though mature in thymus (T lineage), and stay in lymph nodes (B lineage)
are still produced from marrow. so whats the life-time of lymphoid cells.
i mean if the marrow is dead forever, how long does it take for the "already generated lymphoid cells" to get depleted.
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| 1.ammara
Forum Junior
Topics: 8
Posts: 70
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well, the life span of T cells is months to years depending on the needs of the body and that of B cells is weeks to months, so T cells live longer than B cells. but yah, both these cells have self-renewal property in their residing sites i.e lymphoid tissues so that their no. is not reduced. but, this raises another question in my mind, if its so, then that means lymphocytes once formed from the stem cells in the bone marrow in the early years of life when immunce system is developing, contnue to self renew and profilerate in the lymphoid tissue and dont have anything to do with the bone marrow stem cells again?? can anybody explain this....
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| taipei817
Forum Newbie
Topics: 1
Posts: 69
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my opinion is that this guy has a immune reaction (ESR elevation) to all his blood cells, maybe a wrongful transfusion process. would like to check complement levels.
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