jafar_rizvi
Forum Newbie
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Hi.
I wanted to understand the concept of Hypercalcemia and Hypocalcemia. How do they affect the RMP of muscles?
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| taipei817
Forum Newbie
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not much effect in theory(use Nerst equation to figure out) but hypocalcemia decreases the threshold for action potentials.
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| garret
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hypocalcemia => sensitize Na channel (by decreasing blockage of Na channel) => easily depolarize => hyper-excitability
hypercalcemia => desensitize Na channel (by increasing blockage of Na channel) => hardly depolarize => hypo-excitability
but i don't think it has a great effect on resting membrane potential
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