Justice
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At a routine office visit, a 42-year-old woman mentions that her episodes of recurrent genital herpes have become more frequent. Your records show that she received treatment for five episodes in the last 11 months, and she states that she did not even seek therapy for three episodes. She asks if anything can be done to prevent these episodes.
Which of the following treatment regimens will most likely reduce the number of episodes of genital herpes in this patient over the next year?
A. Topical acyclovir daily for 1 month
B. Intravenous acyclovir daily for 21 days
C. Oral acyclovir, valacyclovir, or famciclovir daily for 21 days
D. Oral prednisone plus oral acyclovir daily for 1 week every month
E. Oral acyclovir, famciclovir, or valacyclovir daily to be taken indefinitely
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| ganesha123
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E
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| Markus2009
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E
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| sandra
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e
justice, can u plz post the right answers to ur qs..
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| liliaeliz
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 :
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| cool doctor
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E?
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| CocaCola
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E based on the commercials on TV... 
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| peter90036
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lol CocaCola
lets have herpes together 4 ever
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| Justice
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The correct answer is E
Frequent recurrences of genital herpes can be effectively prevented by chronic suppressive therapy with an oral drug active that is against herpesvirus. Acyclovir (400 mg twice daily), famciclovir (250 mg twice daily), or valacyclovir (500 or 1000 mg daily) can be used. Chronic suppression is usually initiated when a patient has at least six episodes yearly. Most patients will experience some benefit, and 40% to 72% will be free of recurrences at 1 year. Chronic use of these drugs also suppresses asymptomatic virus shedding, so that transmission to others may theoretically be reduced. However, patients on suppressive regimens should be told that they may still transmit herpes simplex virus to their partners. Occasional interruption of therapy is reasonable in order to judge the pattern of recurrences, although there is no evidence that suppressive therapy will decrease the frequency of episodes after the drug is stopped.
There currently are no data to suggest (and no theoretical basis to believe) that any regimen other than daily therapy indefinitely with a drug active against herpes simplex virus can suppress genital herpes.
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