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Prep4USMLE Forum » USMLE Step 1 Forum » Pharmacology Forum

Author

5 Posts

matty
Forum Newbie

Topics: 12
Posts: 24

04/08/04 - 03:55 PM

tetracyclin is found to be therapeutically effctive when 250mg of drug are present in the body the t1/2 of tetra is 8 hrs.what is the correct rate of infusion?

crista
Forum Guru

Topics: 121
Posts: 408

04/08/04 - 05:26 PM

it's something wrong in my calculation bz i don't get the answer.
help..........

crista
Forum Guru

Topics: 121
Posts: 408

04/09/04 - 01:56 PM

hei, some help will be welcomed

mistral92
Forum Senior

Topics: 4
Posts: 185

04/10/04 - 05:13 AM

half life TETRA is 8 hrs
effective when 250mg is present in the body
infusion rate is???

1/2 life = 0.7*VD/ CL= 0.7/Ke ( Ke= first order rate constant for drug elimination)
1/2 life = 0.7/Ke then ......Ke = 0.7/8 = 0.0875
RO= Ke* A ( A= amount of drug in the body= C*VD= 250)
RO = infusion rate
RO= 0.0875* 250= 21.875
do you have the answer matty??? :?

matty
Forum Newbie

Topics: 12
Posts: 24

04/10/04 - 11:20 AM

yes
you are right!!! i should say u r great!!
ans is 22.

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