Justice
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A 45-year-old woman is planning a 2-week trip to Kenya. Her itinerary includes overnight stays in several game parks. She has mild osteoarthritis, no known allergies, and takes no prescription medications. She seeks your advice regarding prevention of malaria.
Which of the following is indicated for prophylaxis of malaria in this patient?
A. Chloroquine
B. Quinine
C. Atovaquone/proguanil (Malarone ®)
D. Metronidazole
E. Trimethoprim/sulfamethoxazole
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| WaqasQureshi
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C
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| dr.wad
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A
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| peter90036
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c ....... ?
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| cool doctor
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A
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| Markus2009
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C
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| CocaCola
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???
C -
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| milestogo
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A
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| aspire
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OMG! Right answer please..
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| vibrio
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c.
chloroquine sensitive areas:some parts of North America(west of panama canal)
parts of Central Asia,some parts of North Africa.Rest of places across globe have resistant falciparum.
drugs in chloroquine resistant areas:malorone-1 day before travel to 1wk after leaving the area.
thanks.
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| liliaeliz
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c
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| Justice
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The correct answer is C
There are several effective forms of malaria chemoprophylaxis for the protection of travelers to areas of risk within sub-Saharan Africa. Currently available medications include mefloquine, doxycycline, and atovaquone/proguanil (Malarone®). The efficacy of these agents is similar, and the choice is based primarily on a consideration of convenience, cost (atovaquone/proguanil is the most expensive), and likely adverse effects. Each chemoprophylactic regimen must begin prior to entry into the malaria-risk area and be continued for 1 week (atovaquone/proguanil) to 4 weeks (doxycycline and mefloquine) after leaving the area.
Chloroquine resistance is widespread. As a result, chloroquine chemoprophylaxis is still effective in only a few areas of the world (for example, Central America, the Caribbean, North Africa, and parts of China). Chloroquine is not an appropriate prophylactic agent for the prevention of malaria in any area of sub-Saharan Africa. In some instances, quinine can be used for the treatment of malaria, but this drug is not currently recommended for chemoprophylaxis. Metronidazole and
trimethoprim/sulfamethoxazole have no significant anti-Plasmodium activity and therefore play no role in the chemoprophylaxis of any form of malaria.
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