fandarast
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Please help clarify if tocolytics are used (can be used) for premature contractions and PROM?
Thanks in advance.
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| jasmin
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TOCOLYTICS ARE USED IN BOTH CONDITIONS ONLY FOR SHORT PERIOD FOR STEROID COVERAGE
Preterm premature rupture of the membranes nearly always leads to preterm labor and delivery. Preterm delivery accounts for most of the morbidity attributable to PPROM. Antibiotic and corticosteroid treatment may modify the outcome of pregnancy after PPROM. The extent of morbidities attributable to PPROM also justifies consideration of the use of tocolysis, at least for a limited period of time (48 hours) after preterm amniorrhexis. When begun after the onset of contractions following PPROM, tocolysis generally does not prolong the latency period, although some prolongation may occur before 28 weeks gestational age. Prophylactic tocolysis begun before the onset of labor increases the likelihood of delaying the onset of labor for 1-2 days, but not beyond. Aggressive long-term tocolysis may increase the maternal risk of chorioamnionitis and endometritis
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| jasmin
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Tocolytic drugs can prolong pregnancy for at least 48 hours and possibly up to 7 days, but there is no convincing evidence of reduction in preterm delivery or perinatal morbidity or mortality. The delay in delivery afforded by a tocolytic agent, however, allows time for the administration of corticosteroids, which is associated with a significant reduction in neonatal morbidity and mortality.The neonatal benefits of tocolysis combined with steroid administration may outweigh the maternal risks, particularly in the setting of extreme prematurity.
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| fandarast
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Topics: 15
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Thanks jasmin! What's the info source?
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