mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
Can anyone explain -what occurs in the "Space of This",also where is it?
___________________
Smell the coffee! "Is That an Osler move??"
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
Did you meant space of disse ? :roll:
|
| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
Just wanted to see if anyone was sleeping-I know at least one who was'nt.
The q is really "THE SPACE OF DISSE"!
To understand this you have know the basic unit the liver lobule
1)The ultimate goal of the hepatic a. and the portal v.(receiving absorbed
material from the gut is the central vein.(The central vein is actually the
beginning of the hepatic vein.
2)Bile formed in the hepatic cell conduits thru the bile canaliculi between
hepatic cells eventualy to the bile duct. (separate from blood cirulation)
3)Sinusoids connect the central vein to the portal v. and hepatic a.
**hepatocytes do Not come in contact with the blood streambut they do
come in contact with lymph!
4)Sinusoids are lined with endothelial cells and macrophages(Kupffer cells)
5)Endothelial cells are also called sinusoidal lining cells
6)The "Space of Disse" is between the endothelial cells and the
hepatocytes. The Space houses microvilli of hepatocyes,
Ito cells(they store fat and Vitamin A) and slender reticular fibers
form the frame work of the liver.
7)The Space of "Disse" is very permeable and has large pores. The millions
of spaces of "Disse" connect with lymphatics in the interlobular septa.
8).Hepatic sinusoids are very very permeable fluid and protein gets into
the space of "Disse", so lymph draining from the liver has protein
concentration close to that of plasma. Under resting conditions half of
all lymph comes from the liver.
9)**High hepatic venous pressure---excess fluid transudates into lymph--
also leaks thru outer surface of liver--into abdomen--thats ASCITES
10)A picture is worth a thousand words. Id strongly recommend looking at
a pic of a liver lobule in ahistology atlas, Guyton.or good anatomy book
because my edition of BRS physio didnt even have the word liver in the
index and it read mostly about bile acids.
: :shock:
___________________
Smell the coffee! "Is That an Osler move??"
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
Thanks mjl 8)
and last but not least point is that space of disse / perisinusoidal space is from where uptake of bilirubin takes place .
|
| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
This how I see bilirubin formation according to Guyton
1)old RBC phagocytized by macrophages
2)hemoglobin split to heme& globin
3)The globin part (four pyrrole nuclei) is the substrate that bilirubin will be
formed
4)biliverdin 1st to bilirubin is release from macrophages to the plasma
5)bilirubin is bound to albumen but still called free bilirubin
6)bilirubin is absorbed thru hepatic cell membrane and released of albumen
7)Bilirubin is mostly conjugated with glucuronic acid
8)** OK asmi I see your point after looking at this circuit or cycle-The
sinusoids are very permeable-so we have bilirubin input from the
"Space of Disse" and bilirubin output or excretion by active transport
into the bile canaliculi.
___________________
Smell the coffee! "Is That an Osler move??"
|
|
| |
| | | | | |
