new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,056
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I had found an article a long time back that explained the relationship between MG and Thymoma but cant seem to find it anymore.
The gist of the article i had written from it was that MG is a B-cell Disease and Thymoma or Thymic disorders tend to give rise to T-cell abnormalities. Now in the peripheral lymph nodes the T-cell and B cells interact to form antibodies against the ACh Receptor. It was interesting to note that those patients with MG had a different histological picture of thymus than those MG patients with Thymoma. Most patients with MG will have a thymic hyperplasia with Germnial Centres of Bcells producing the antibodies while patients of MG with thymoma will have no germnial centre but tumor cells are of epithelial origin. Making the possibility of co-existence in both in the thymus.
Now the thymus has the Self antigen recognition part and the cells which recognise or bear the ACh receptor are the myoid cells ( which become the source of the antigen), the antigen presenting cells and the T-cells which recognise self antigens.
In essence the thymus myoid cells get a hit or get deranged in a way that leads development of antibodies to ACh receptor. Now whether the thymus plays a primary or secondary role is very very debateable and under investigation.
I hope i have tried my best but if you have questions please do ask.
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| Tiff
Forum Guru
Topics: 54
Posts: 562
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 Thanks. It helps.
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