mikejonathan200
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Well in case of liver failure the portal ciculation will be congested and theat will affect the GIT wall ..they will liable for vein congestion and that why liver failure will lead to esoghageal varices ..so the whole bowel gets disturbed and that will lead to repeated vomiting ...more acid lost ..more potassium lost ....will lead to
Hypokalemic Alkalosis in Liver Failure
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| farnsworth
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mikejonathan: did you look that up? can you give the reference?
Another possible explanation: liver failure leads to a decreases protein/albumin synthesis, the plasma becomes hypooncotic, fluid is shifted from intra- to extravascular (-> ascites, low blood pressure, etc). A compensatory mechanism is a increased renin activity, leading to aldosterone production. Hyperaldosteronism leads to hypokalemia and hypernatremia. The strong ion difference (SID), mainly determined by Na and Cl, to lesser extends by K and HCO3, increases -> alkalosis! (as Cl- is not regulated by aldosterone).
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