oddissy4u
Forum Guru
Topics: 107
Posts: 389
|
wht happens to aldosterone level?
|
| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
increase mineralcorticoids
sex hormones and cotisol decrease,phenotypic female no maturation
___________________
Smell the coffee! "Is That an Osler move??"
|
| oddissy4u
Forum Guru
Topics: 107
Posts: 389
|
thts wht i though but BSS says decreased aldosterone so was confirming,thnx 
|
| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
|
actually I think it would decrease, or be normal, no cortisol, hence, more 11 Hydroxycorty will accumulate, but aldo will decrease because 11-hydroxycorty has mineralo effect, nence renin will go down, hence, no AngII, and less Aldo.
___________________
"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
In 17-OH deficiency, mineralocorticoids are elevated, but glucocorticoids (cortisol) and sex hormones are depressed.
aldosterone would be elevated, and there would be hypertension in a girl with ambiguous genitalia (i think it should be a girl, since there are no androgens)
|
| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
|
you are forgetting about 11-hydroxycortisole, made by 21-b-hydroxylase, it has weak meneralo effect, but in large quantities, it will depress renin, and Aldo production.
___________________
"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
Hes right, I looked it up. They do have salt retention and hypertension, but from elevated DOC, which actually suppresses aldosterone. My apologies. I was looking at clinical presentation with checking my biochem facts.
|
| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
|
My pleasure :-)
___________________
"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
|
| oddissy4u
Forum Guru
Topics: 107
Posts: 389
|
thnx
|
| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
My mistake -Looking at Robert Dunns lecture (kaplan)aldosterone decreased , DOC increased and supposedly DOC works as a weak mineralcorticoid. (Thats why I do not like to depend on first aid too much.)
___________________
Smell the coffee! "Is That an Osler move??"
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
"mjl1717" wrote:
My mistake -Looking at Robert Dunns lecture (kaplan)aldosterone decreased , DOC increased and supposedly DOC works as a weak mineralcorticoid. (Thats why I do not like to depend on first aid too much.)
In defense of FA, they do say increased mineralocorticoids and I think we should take from this that the child will be hypertensive due to salt retention. The extra is nice, but the clinical picture stays the same no matter how you look at it.
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
"mdwannabe" wrote:
you are forgetting about 11-hydroxycortisole, made by 21-b-hydroxylase, it has weak meneralo effect, but in large quantities, it will depress renin, and Aldo production.
btw, you shouldnt have any 11-deoxycortisol, since you cant get to the 17-OH progesterone pathway. You may be thinking of 11-doexycorticosterone?
|
|
| |
| | | | | | | | | | | | |
