oddissy4u
Forum Guru
Topics: 107
Posts: 389
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wht dopes T3 resin uptake measure n its decreased n increased under which conditions?
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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T3rU measures the amount of T3 that is taken up by the 'observer' after infusion.
A high T3rU means that the patient has many bound TBG sites (i.e. hyperthyroidism) while a low T3rU means that a patient likely has many sites that are not bound by T3/T4 (i.e. hypothyroidism)
In short: you put 100% T3 in, and it binds...what doesnt bind, comes out and is called the resin T3 uptake. The higher the number, the more endogenous thyroid hormone is present, more or less (I am sure there are exceptions...given the way my luck is going tonite :lol: )
Hope Im right...
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| dr.shar
Forum Elite
Topics: 38
Posts: 236
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decreased in hypothyroidism
increased in hyperthyroidism
decreased in pregnency coz of increased synthesis of TBG
increased in a person who is taking anabolic steriods coz of decreased synthesis of TBG.
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| Sakaki-
Forum Senior
Topics: 1
Posts: 238
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Actually, the T3 resin uptake does not measure the free amount of hormone; it only is a measure of the number of unoccupied thyroid hormone-binding sites on TBG. It is a competition assay that involves a labelled T3 (ex. luminescent) and the T3 in the patient serum.
If there are an increased number of available binding sites on the TBG, more labelled T3 will be bound by TBG, and there will be less available labelled T3 available to bind to the resin (or solid matrix), so the T3 uptake (which is the proportion of radioactivity bound by the solid matrix) decreases.
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