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8 Posts

crista
Forum Guru

Topics: 121
Posts: 408

04/05/04 - 03:30 PM

what is the mechanism of vasodilatation for acetylcholine? i read that vessels don't have parasymp. inervation but there are some colinergic rec. in vessels that make vasodilatation.how is this possible?

usmleasr
Forum Guru

Topics: 105
Posts: 970

04/05/04 - 03:43 PM

yeah...M3 receptors on vessels on ...stimulation causes vaso dilation.....vessels donot have innervation from parasympathetics...so only direct acting parasympathomimetics never with indirect acting drugs

crista
Forum Guru

Topics: 121
Posts: 408

04/05/04 - 03:48 PM

so M3 acts by phospholiapse C which increases the intracellular Ca;how this can determine the formation of NO?

bims
Forum Senior

Topics: 26
Posts: 118

04/06/04 - 01:27 PM

blood vessels are solely innervated by SANS however the endothelium of most blood vessels releases EDRF/NO in response to muscarinic stimuli :arrow: vasodil.however these muscarinic receptors are not innervated so respond only to circulating muscarinic agonists and not intrinsic ach.i dont think it goes thru phospholipase c steps.

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oddissy4u
Forum Guru

Topics: 107
Posts: 389

04/06/04 - 01:31 PM

bIms is right.

bims
Forum Senior

Topics: 26
Posts: 118

04/06/04 - 02:57 PM

thanks :icon_cherry:

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dr.shar
Forum Elite

Topics: 38
Posts: 236

04/06/04 - 09:14 PM

good question idea

santaclara
Forum Elite

Topics: 67
Posts: 299

04/19/04 - 11:37 AM

TO bims
HEY I THINK READ THE MACHANISM OF (ACETYLCHOLINE) FROM LIPPINCOTT.
IN LIPPINCOOT THEY TOLD THAT THERE IS NO INNERVATION TO BLOOD

VESSELS THROUGH PARASYMPATHETIC SYSTEM BUT THERE R CHOLINERGIC RECEPTORS ON THE VESSELS THAT CAUSES
VASODILATION.IF WE GIVE THE INJECTION OF ACETYLCHOLINE.
AND VASODILATION IS DUE TO AN ACETYLCHOLINE INDUCES RISE IN INTRACELLULAR (Ca++)-CAUSED BY THE PHOSPHATIDYLINOSITOL SYSTEM-THAT RESULY IN THE FORMATION OF NITRICOXIDE(NO)FROM ARGININE IN THE ENDOTHELIUM(NO OR EDRF)

MAY BE I M WRONGCORRET ME PLSSSSSSSS. :roll:

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