guangyu
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An otherwise healthy 7-year-old girl is brought to your office by her father because she has some acne, breast development, and fine pubic hair. Which of the following is the most likely etiology for her condition?
A. A feminizing ovarian tumor
B. A gonadotropin-producing tumor
C. A lesion of the central nervous system
D. Exogenous estrogens
E. Early onset of "normal" puberty (constitutional
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| sandra
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e?
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| farnsworth
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D? nibbling mommies OCPs?
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| dr.wad
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( E ) ....idiopathic precocious puberty is responsible for 80% of cases.
but u have to exclude other causes first.
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| Miradautas Vras
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Why axillary hair absent?? no endogenous androgens produced yet, which should exclude precocious puberty [ that's sort of guessbut i'd go with it] Exogenous estrogen looks like an option.
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| guangyu
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The patient in the question appears to have "true sexual precocity," implying that the gonads have matured in response to the secretion of pituitary gonadotropins and have begun secreting sex steroids, causing the development of secondary sexual characteristics. Thus, ovarian tumors and exogenous estrogens, which suppress the function of the pituitary gland, do not cause true precocious puberty. In girls, the most common form of true precocious puberty is idiopathic and is thought to be caused by early maturation of an otherwise normal hypothalamic-pituitary-gonadal feedback system. In boys, true precocious puberty is relatively rare and is more likely to be caused by lesions of the central nervous system. Gonadotropin-producing tumors, which are very rare, can cause true precocious puberty in both sexes.
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| pr20
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Thnx for the ques.
Does this mean that a feminizing ovarian tumor(like a granulosa cell tumor)will not cause precocious puberty in females OR relatively not a common cause compared with others??
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