anne
Forum Elite
Topics: 41
Posts: 348
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A 10-year-old male presents to the pediatrician's office with poor academic performance. His past medical history reveals that he is deaf, is moderately mentally retarded, and has ‘stiff joints.’ On exam, you note short stature and coarse facies. An eye exam reveals that the corneas are clear. An oral exam shows a large tongue. Heart, lung, and abdominal exams are within normal limits. The complete blood count and electrolytes are normal, but the patient's urine is positive for increased dermatan sulfate and increased heparan sulfate. In which enzyme is this child most likely deficient?
A. Alpha-iduronidase
B. Beta-glucuronidase
C. Heparan sulfamidase
D. Iduronosulfate sulfatase
E. N-Acetylglucosaminidase
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| usmleasr
Forum Guru
Topics: 105
Posts: 970
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D.iduronate sulfatase(hunter's) :roll:
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| dr.shar
Forum Elite
Topics: 38
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A. Alpha-iduronidase
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| anne
Forum Elite
Topics: 41
Posts: 348
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ans=D
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