jihyunrhee
Forum Newbie
Topics: 9
Posts: 21
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29. A new analgesic drug that will decrease pain at sites of acute inflammation is to be developed. This action can be achieved by creating an antagonist to which of the following inflammatory mediators?
A ) Bradykinin
B ) C5a
C ) Histamine
D ) Interleukin-2 (IL-2)
E ) Prostacyclin
F ) Transforming growth factor
I thought it was C
Both histamine and bradykinin mediates pain
Ir's in Robbins
Histamine is released as preformed substance at the inflamatory site
BUT Bradykinin also is a pain mediator that is released from mast cells as
secondary substance (newly synthesized)
I've looked at the prebious posts but didn't have any comments about
histamine~
Could somebody explain why A is a better choice than C?
I really think A & C both could be the answer
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| angel23
Forum Guru
Topics: 38
Posts: 780
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its A....
pain in inflammation is not mediated by histamine...
its bradykinin and PGE2...acc to goljan...
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| jihyunrhee
Forum Newbie
Topics: 9
Posts: 21
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thanks angel~
I'll remeber them
PGE2 and bradykinin for pain
does that mean histamine is for allergic pain?
I mean is there pain sensation when there's allergy
I'm a little confused
When does histamine mediate pain sensation
I remember reading from UW that
during inflammation pain is mediated by
1. Histamine
2. Bradykinin
3. n. ending compression by edema
that's how I remeber it
plz cud somebody clarify?
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