help again - macrocytic anemia

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help again - macrocytic anemia

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6 Posts

Tiff
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Topics: 54
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02/20/08 - 01:52 PM

Can anyone help explain how hypothyroidism can cause macrocytic anemia?

fudoc_20
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Topics: 4
Posts: 48

02/20/08 - 02:41 PM

hypothyroidism leads to hypofunction of the intestin with decrease in the absorbtion of folic acid

jean robert
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02/20/08 - 02:47 PM

Macrocytic anemia may be due to pernicious anemia. As pernicious anemia and Hashimoto thyroiditis can coexist as part of a Polyglandular autoimmune (PGA) syndromes (otherwise known as polyglandular failure syndromes) .

Polyglandular autoimmune are constellations of multiple endocrine gland insufficiencies.

Not sure of mechanism.

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jean robert
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02/20/08 - 02:50 PM

Essentially, 2 types exist, type I and the more common type II, also known as Schmidt syndrome. A third type (type III) has been described, which occurs in adults. Type III does not involve the adrenal cortex, but it includes 2 of the following: thyroid deficiency, pernicious anemia, type 1A diabetes mellitus, vitiligo, and alopecia. Other, newer disorders have been described recently in association with the PGA syndromes; pulmonary hypertension in association with PGA-II is one example

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Tiff
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Topics: 54
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02/21/08 - 05:15 PM

Thanks guys. really helps. smiling face

wyb
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Topics: 8
Posts: 43

02/22/08 - 01:56 PM

Thanks for the explanation! I just listened Goljan's lecture about Dementia due to B12 deficiency, and how to differentiate from the one due to hypothyroidism. nod

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