Tiff
Forum Guru
Topics: 54
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Anyone know how the following r associated with increased bone turnover?
Breast feeding, Pregnancy, hyperthyroidism
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| new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,085
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In pregnancy and lactation there is a specific relationship of calcium transfer from mother to fetus and to child through milk. This part i knew the mechanism i didnt so had to look it up. Came up with a good article. The gist was that there is a cytokine osteoprotegerin (OPG)/osteoclastogenesisinhibitoryfactor (OCIF); this cytokine inhibits osteoclast maturation.
The levels of bone resorption were balanced by high PTH activity and increased intestinal calcium absorption under increased Vit D activity. Though immediately after partum the levels dropped of these 2 hormones resulting in the increased bone resorption occuring due increased transport of Calcium in breast milk. PTHrP is another susbtance found in breast milk which is said to have increased the presence of calcium in breast millk. However the balance is offset by reduced levels of VitD and OPG thus leading to an increased bone turnover.
http://journals.endocrinology.org/joe/174/0353/17...
http://jcem.endojournals.org/cgi/content/full/86/...
THYROID HORMONE exerts its effect on osteoblasts via nuclear receptors to stimulate osteoclastic bone resorption; hyperthyroidism is thus one of the major causes of secondary osteoporosis
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| Tiff
Forum Guru
Topics: 54
Posts: 563
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Thanks for explainng this. These articles are great. Thank u much. Really clears things up. 
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