Summer.Thunder
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qbook, physio 2, question 16
answer has: "pancreatic glucagon release acts as paracrine stimulus for insulin secretion?"
is that correct? i thought that glucagon and insulin have opposite effect, so how can this be correct?
if so, why?
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| maoudoody
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glucagon increases glucose and thus stimulates insulin secretion
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| maoudoody
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also return to kaplan physio review book page 407
there is a diagranm that illustrates this fact
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| maoudoody
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sorry the paracrine action is not due to the fact that glucagon elevates glucose
it is due to that the amino acid sequence of glucagon is similar to the duodenal hormone secretin
and so like secretin it stimulates insulin secretion
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| pari99
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Yes.. you r correct..glucagon has opposite action than insulin..that is it increases liver glycogenolysis and gluconeogenesis etc.but those r peripheral actions
However acting locally on beta cells it stimulates insulin release.(paracrine action=local action)
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| maoudoody
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yes increasing glucose is a peripheral not paracrine action
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| Summer.Thunder
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oh, i did not know that, so what is the insulin's action on glucagon then?
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| maoudoody
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insulin has an inhibitory paracrine action on glucagon
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