Very tricky

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Very tricky

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jean robert
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02/09/08 - 05:07 AM

A drug is given that produces vasodilation by increasing cGMP in the smooth muscle cells of arterioles. Which of the following drugs has this mechanism of action?

a) Bethanechol

b) Isoproterenol

c) Metaproterenol

d) Nifedipine

e) Phentolamine

f) Phenylephrine

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pr20
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02/09/08 - 08:59 AM

a) Bethanechol
Direct acting parasympathomimetics(like bethanechol)---->release nitric oxide from endothelium---->activates guanylyl cyclase---->generates cGMP---->relaxation of smooth muscle.

new_n_lost
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02/09/08 - 01:36 PM

pr20 wrote:
a) Bethanechol
Direct acting parasympathomimetics(like bethanechol)---->release nitric oxide from endothelium---->activates guanylyl cyclase---->generates cGMP---->relaxation of smooth muscle.

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jean robert
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02/21/08 - 12:06 PM

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