Increase in BP

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Increase in BP

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jean robert
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02/08/08 - 09:17 AM

Which of the following drugs will cause an increase in BP after chronic administration of reserpine?

a.- Amphetamine

b.-Bethanechol

c.-Cocaine

d.-Guanethidine

e.-Phenylephrine

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nerve09
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02/08/08 - 10:06 AM

A.
..i have to ask...whr do u find questions like these??..seriously most of it i have to search n read n only then i can answer nod

gud questions jean nod

thank u

new_n_lost
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02/08/08 - 06:27 PM

e.-Phenylephrine

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pr20
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02/08/08 - 11:49 PM

e.
Decongestants like phenylephrine and pseudoephedrine may counter the blood pressure effects of reserpine.

jean robert
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02/09/08 - 01:17 AM

new_n_lost wrote:
e.-Phenylephrine

Correct answer :E

Reserpine acts by blocking vesicular uptake of monoamine neurotransmitters (NE, dopamine, serotonin), thus making the neurotransmitter vulnerable to the catabolic effects of monoamine oxidase (MAO) present in the nerve terminal.

High doses of reserpine can even destroy synaptic vesicles. Chronic administration of reserpine causes depletion of NE. Therefore, for a drug to raise BP after NE depletion, it must act directly on the alpha1 adrenergic receptors present on arterioles.

Phenylephrine, a direct alpha1 agonist, is such a drug.

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vaibhavbora
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08/17/08 - 01:16 PM

good q

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aml
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08/29/08 - 11:39 AM

good question

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