jean robert
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38 y.o. woman presents to a physician for a routine examination. During pelvic examination, the physician notes several raised verrucous lesions on the vulva. A biopsy of one such lesion reveals treelike proliferartion of the epithelium associated with a fibrous stroma. At which of the following skin layers does the causative agent of this woman s condition normally infect cells?
a) Stratum Corneum
b) Stratum Lucidum
c) Stratum Granulosum
d) Stratum Spinosum
e) Stratum Basale
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| arlete
Intern in 2009!!!!!
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A
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| Tiff
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E - stratum basale
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| CocaCola
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e - basale - HPV infection
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| jean robert
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Correct answer is E
HPV infection promotes the outgrowth of the basal layer, increasing the number of prickle cells. This causes the skin to thicken and promote the production of keratin, thus causing epithelial spikes to form. Serotypes 6 and 11 are the most common and benign whereas serotypes 16 and 18 are strongly associated with CIN.
The new recombinant vaccine contains capsids of serotypes 6,11,16 and 18. The treatment for HPV is usually cryotherapy or imiquod.
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