angel23 wrote:
e.protein c synthesis....
warfarin prevents gamma carboxylation so prevents release of factors...
factor 7 and prt C hav shortest half-lives....so prt C decreases....induces a litl coagulation responsible for skin ulceration
Thats why I hated step1 so much, to much detail. And lets not talk about molecular biology.
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| jean robert
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Protein C has a short half life (6 hours). When patients are placed on Warfarin, protein C activity falls to zero activity in 6 hours, causing a hypercoagulable state due to increased activity of factors V and VIII.
This causes cutaneous vessel thrombosis and concomitant skin necrosis. This is common in heterozygote carrier of protein C deficiency placed on Warfarin because they only have 50% protein C activity.
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| Tiff
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E. Protein C synthesis
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| vaibhavbora
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e-protein C synyhesis
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