silver
Forum Guru
Topics: 21
Posts: 774
|
54 yr. old white male presents with gradual onset of mild dementia, ataxic gait, and startle myoclonus. MRI scan is normal, examination of CSF reveals no abnormalities, but EEG is remarkable for recurrent bursts of high-voltage slow waves. Over the next 6 months, patient's dementia rapidly worsens, accompanied by general hypertonicity and profound dysarthria. The patient dies shortly thereafter. Which of the following is the most likely neuropathological finding at autopsy?
A. Cerebellar hyperplasia
B. Diffuse spongiform change
C. Multiple lacunar infarcts
D. Negri bodies
E. Neurofibrillary tangles
___________________
Every disaster hides an opportunity.
|
| Tiff
Forum Guru
Topics: 54
Posts: 563
|
B
|
| docdoc9
Forum Elite
Topics: 28
Posts: 221
|
Creutzfeld Jacob Disease...diffuse spongiform change
|
| new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,086
|
B. Diffuse spongiform change
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| paheli
It'sAllAboutGoodKarma
Topics: 177
Posts: 2,368
|
B
___________________
Prepare as if you're the worst, Perform as if you're the best! As you dream, so you manifest. So, DREAM BIG!! When you face hardship, remember, God never gives you more than you can handle. Keep your face to the sunshine and you cannot see the shadows.
|
| silver
Forum Guru
Topics: 21
Posts: 774
|
CORRECT ANSWER: B
The rapidly progressive dementia in this case is characterisitic of Creutzfeldt-Jakob disease (CJD). The dementia is usually accompanied by motor dysfunction and abnormal EEG activity. The pathological hallmark of this disease is spongiform change in gray matter. Death usually occurs within 6-12 months of disease onset.
At autopsy, the cerebellum in CJD appears atrophic, not hyperplastic (A).
Multiple lacunar infarcts (C) are seen in vascular dementia, and patients typically present with focal neurologic signs. Additionally, vascular dementia typically presents with a more gradual decline in cognitive function, measured in years rather than months.
Negri bodies are pathognomic for rabies.
Neurofibrillary tangles are seen in Alzheimer's disease. There is a more gradual decline in cognitive function, measured in years rather than months.
___________________
Every disaster hides an opportunity.
|
|
| |
| | | | | | |
