bright_nnn
Forum Senior
Topics: 17
Posts: 97
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How does excess Phosphate cause Metastatic calcification.?
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| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
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It binds available Calcium and get outa solution.
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Think about it this way:
Calcification is phosphate dependent (paradoxically), which is why PTH, which wants to put Ca++ in solution, actually spits out phosphate. Phosphate will drive Ca++ into tissues when the product of the Ca++ and phosphate concentrations > 55.
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| oddissy4u
Forum Guru
Topics: 107
Posts: 389
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whts the diff b/n metastatic calci n dystrophic calcif ?egs?
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Metastatic calcification occurs when normal tissue gets calcified (i.e. in renal failure, normal cartilage gets calficied)...usually due to high levels of Ca++ and/or phosphate
Dystrophic calcification occus when damaged tissue gets calcified (i.e. calcified muscle after njury, calcified atheromatous plaques)
Question: does a congenital bicuspid aortic valve that gets calcified qualify as metastatic or dystrophic?
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| oddissy4u
Forum Guru
Topics: 107
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metastatic?
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Its tricky, but it is dystrophic. The tissue is abnormal, and we should think of it as damaged. The calcification occurs without any serum Ca++/phosphate abnormalities...we should make that our deciding factor here.
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| oddissy4u
Forum Guru
Topics: 107
Posts: 389
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tht sure was tricky.thnx for the info.
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