pr20
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A Pap smear of a 23-year old woman demonstrates squamous cells with enlarged,hyperchromatic nuclei and prominent perinuclear halos.The Pap smear is graded as cervical intraepithelial neoplasia,grade 2(CIN 2).The mechanism of oncogenesis for this causative agent is most closely related to the mechanism of oncogenesis for which of the following cancers?
A.Burkitt lymphoma
B.Familial adenomatous polyposis coli
C.Malignant melanoma
D.Osteosarcoma
E.Wilms tumor
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| new_n_lost
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B.Familial adenomatous polyposis coli ??
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| docdoc9
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cells described r koilocytes characteristic of human papilloma virus.HPV has E6 and E7 which act on p53 and Rb genes respectively
Therefore osteosarcoma (caused due to inactivation of Rb)
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| Tiff
Forum Guru
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B. Familial adenomatous polyposis coli
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| new_n_lost
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HPV is the promoter of the cervical carcinoma rather than the main cause of oncogenesis.
CIN and FAP are both originating from precancerous lesion which have dysplasia as the common factor in both. The higher degree of dysplasia the higher the chances of a cancerous lesion.
Again Moi 2 cents.
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| jean robert
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D
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| pr20
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Answer is D.
Atleast 85% of all cases of CIN are associated with infection with HPV serotypes 16 and 18.The description of enlarged,hyperchromatic nuclei and prominent perinuclear halos is consistent with the koilocytotic atypia characteristic of this infection.HPV possesses two proteins,E6 and E7,which combine with and inactivate tumor suppressor genes p53 and p105Rb,respectively.Damage to the p53 tumor suppressor gene is involved with the production of the Li-Fraumeni syndrome,and damage to Rb is involved in retinoblastoma,osteosarcoma,and some carcinomas of the breast,colon,and lung.
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| Tiff
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I guess the question was asking "mechanism of oncogenesis". Totally missed this.
Really important to read carefully and actually absorb the info. 
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