angel23
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hav to do today 278 ques of pharma kaplan qbank....+ FA + HY pharma+ ANS and general 4rm book....
started dng ques first....
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| SOS
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keep it up ,you are doing great...
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| cutekity
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good going angel ....keep working hard !! goood luck ....
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where there is will, there is always a way !!
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| milee99
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hard work pays !!
u will do well
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"Vasudhaiva Kutumbakam" - The whole earth is my family.
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| angel23
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answer is C. nothing is mentioned in the question stem abt the h/o contact with a T.B patient or the risk factors so we assume that the above mentioned persons (except HIV pt.)are not a high risk pts.
according to CDC guidelines in HIV > 5 m.m but here its 4 m.m and if no risk factors mentioned it shld be >15 m.m none of the above optiones have > 15 m.m
last one if age is <35 yrs and induration >10 m.m then he shld receave INH prophylaxis.
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| angel23
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5 mm or more induration is a positive reaction
in the following instances:
1. Patients who have recently had close contact
with a person with an active case of tuberculosis
2. Patients with fibrotic lesions on chest
radiograph consistent with past healed
tuberculosis
3. Patients with known or suspected HIV infection
10 mm or more induration is a positive reaction
in the following instances:
1. Patients with certain high-risk health conditions
(Table 1)
2. Patients from other countries with a high
prevalence of tuberculosis
3. Medically underserved high-risk minorities
(blacks, Hispanics, Native Americans)
4. Injecting drug users
5. Residents of long-term care facilities
6. Other high-risk populations identified by local
health departments
15 mm or more induration is a positive reaction-All groups not mentioned above
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| angel23
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Candidates for Isoniazid Chemoprophylaxis
Positive PPD, regardless of age:
1. Persons with HIV infection ([more than or equal to] 5 mm)
2. Persons with risk factors for HIV, but of
unknown status ([more than or equal to] 5 mm)
3. Close contacts of infectious cases ([more than or equal to]
5 mm),
including PPD-negative children ([more than or equal to] 5 mm)
of
newly diagnosed patients until a repeat PPD
at 12 weeks
4. Recent converters under 35 years of age with
[more than or equal to] 10 mm or induration
5. Recent converters over 35 years of age with
[more than or equal to] 15 mm of induration
7. Those with fibrotic changes on chest radiograph
indicating past healed tuberculosis ([more than or equal to]
5 mm)
8. Injecting drug users known to be HIV-seroneg-
ative with [more than or equal to] 10 mm of induration
9. Persons with high-risk medical conditions with
[more than or equal to] 10 mm (see Table 1)
Positive PPD, in those less than 35 years of age
with [more than or equal to] 10 mm of induration:
1. Patients from another country with a high
prevalence of disease
2. Medically underserved low-income populations
3. Residents in long-term care facilities
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| angel23
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thanks SOS,cutekity and milee for dropping by....
time is going so fast.....
anyways hav a target of dng bchem 2day +genetics+molecular
havnt done these 4rm a long time + will do ques 4rm kaplan....expiring 2mrw
good luck to me....
plz anyone tell me wat all is imp in bchem.....wil FA be enough!!
thanx
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| angel23
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i m getting 55-60% in UW ...need to improve my score
so started with theory again
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| angel23
Forum Guru
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mineral oil intake .........fat soluble vit def.
B12 stored in liver..
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| angel23
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alpoecia.....B6 def..zinc def and vitA excess
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| antidepressant
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hi angel, i didnt read fa for biochemistry, so i cant coment, and my fa was 2003 edition, it doesnt have all metabolic pathways, and in my test metabolic part of biochemistry was tested heavily. Dont feel down because of your uw score, if its first time, its really great! and its not really assessment tool. are you doing mixed mode? thanks for wishing me in my journal, and thank you for your prayers, one more week to wait for my results.
Keep studying angel, just check the wrong answers in uw, may be educational objectives, do more questions. you will definitely do great!
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CSF value of Glucose 50-75 mg/dl,pressure: 70-180 mm H2O,protein: < 40 mg/dl.alpha1 agonist: phynelephrine, methoxamine.Non selective alpha blocker: Phentolamine, phenoxybenzamine. alpha 2 blocker: yohimbine, mirtazapine
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| angel23
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thanks AD for dropping by...
i m dng ques in timed mixed mode
n coring b/w.....56...-..62 sometimes.....
i do ques in morning....then revise those in afternoon and then by evening dnt hav much time left to revise theory
i hav still 25 blocks of UW to go
so hav to really really work hard!!
my prayers r with u AD...!!
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| angel23
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http://www.prep4usmle.com/forum/thread/66591/
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| SOS
Forum Guru
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that's great thread angel....i just checked it....
seeing such helpful threads... i wish i could do something to thank this forum.
how are you feeling? how's biochem going? this time i haven't read FA yet but i think biochem FA is good... its going to be over soon..... you are at the last leap now,so give your best now.... few more days to go..... wish you lots of luck.
Edited by SOS on 02/15/08 - 06:37 AM
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| step99
Forum Senior
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Posts: 194
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hi angel
i hope u are doing great..how is pharm? dont forget the molecular bio..
these days im just listening dr.francis pass program...really good,make sense..
good luck with your studies..just 10 days left..
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| angel23
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SOS thanks!!i feel same here....this forum has helped me a lott n wish i cud do something i return...wud help others
i m dng FA 4r bchem found tht ok...
yday did genetics,molecular n biostats
tough subjects
2day plan to do 4 qbanks n revise bchem n left over beh.
hav to hav to do this 2day....
i did molecular n genetics n biostats yday 4rm kaplan qbank...
is there any more material 4r molecular....
i mean wat type of molecular is cuming on exam...those PCR,ELISA things or the transcription translation ones????
GL to u too step99
wen is ur exam?
STEP99
thank u so much for dropping....u had been such a great help to me....
my pharma is ok now...it is just i shud devote half an hour daily to the notes u gave...they are awesome!!
i havnt heard of Dr.francis...
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| angel23
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THIS WAS FOR STEP99....how did it go in SOS
anyways this is continuation of my msg step99.....i dnt knw hw to edit here
i did molecular n genetics n biostats yday 4rm kaplan qbank...
is there any more material 4r molecular....
i mean wat type of molecular is cuming on exam...those PCR,ELISA things or the transcription translation ones????
GL to u too step99
wen is ur exam?
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| angel23
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SIROLIMUS
Despite its similar name, it is not a calcineurin inhibitor like tacrolimus or cyclosporin. However, it has a similar suppressive effect on the immune system. Sirolimus inhibits the response to interleukin-2 (IL-2) and thereby blocks activation of T- and B-cells. In contrast, tacrolimus and cyclosporine inhibit the production of IL-2.
The mode of action of sirolimus is to bind the cytosolic protein FK-binding protein 12 (FKBP12) in a manner similar to tacrolimus. However, unlike the tacrolimus-FKBP12 complex which inhibits calcineurin (PP2B), the sirolimus-FKBP12 complex inhibits the mammalian target of rapamycin (mTOR) pathway through directly binding the mTOR Complex1 (mTORC1). mTOR is also called FRAP (FKBP-rapamycin associated protein) or RAFT (rapamycin and FKBP target). FRAP and RAFT are actually more accurate names since they reflect the fact that rapamycin must bind FKBP12 first, and only the FKBP12-rapamycin complex can bind FRAP/RAFT/mTOR
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| angel23
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The chief advantage sirolimus has over calcineurin inhibitors is that it is not toxic to kidneys. Transplant patients maintained on calcineurin inhibitors long-term tend to develop impaired kidney function or even chronic renal failure, and this can be prevented by use of sirolimus instead. It is particularly advantageous in patients with kidney transplants for hemolytic-uremic syndrome as this disease is likely to recur in the transplanted kidney if a calcineurin-inhibitor is used
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