jean robert
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A?
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| new_n_lost
Politically InCorrect
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A. Bleeding in joints >> DOC in CBP is TMP-SMX and SE of it is thrombocytopenia
Edit: Initially i thought this wold be something about a dude who overdosed on Cialis or something and has some other related issues. 
Edited by new_n_lost on 01/26/08 - 04:20 PM
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| KHILADI420
Forum Newbie
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bleeding in joints A
because intestinal bacterial flora is gone. so no vit K no coagulation factors 2,7,9,10. no gamma carboxylation reactions in the liver. Similar to warfarin overdose.
Rx. fresh frozen plasma or vit K or synthetic clottting factors.
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| Tiff
Forum Guru
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Great question. Could be TMP-SMX or Quinolones. TMP-SMX can cause thrombocytopenia. Quinolones really cause tendon problems rather than bone. Think I'll go with choice A.
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| silver
Forum Guru
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CORRECT ANSWER: A. BLEEDING IN JOINTS
To answer this question you have to identify 2 pieces of information. First, you have to recognize that the question is about vitamin deficiency acquired by antiobiotic therapy (Vit. K is made by bacteria in the gut) and then you must recognize the deficiency syndrome that would be produced (bleeding tendency secondary to the inability to make clotting factors II, VII, IX, X, and proteins C & S).
Vit. D deficiency can lead to bony abnormalities.
Vit. A deficiency can cause decreased night vision.
Vit. B12 and thiamine deficiency can lead to neurologic defects.
Vit. C deficiency can lead to scurvy.
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| pr20
Forum Senior
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Yeah answer is A....due to Vit.K.deficinecy secondary to destruction of normal gut flora by chronic use of antibiotics.
I think it cannot be due to thrombocytopenia....bcas platelet disorders will not cause bleeding in to joints,which is a feature of coagulation factor deficiency.Platelet disorders cause epistaxis,petechiae,easy bruising,etc.
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| Tiff
Forum Guru
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 Totally wasn't thinking in that direction. 
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| Idlehands
Forum Newbie
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Its always easier to discuss the answer or say the right words when the explanation has been posted.
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| pr20
Forum Senior
Topics: 20
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@Idlehands
Its always easier to discuss the answer or say the right words when the explanation has been posted....
I don't know whether you are referring me,but Iam only trying to clear small concepts which may mislead all of us....nothing more than that.
Sry if i sound rude.
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