drduck
Forum Guru
Topics: 82
Posts: 529
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can anyone tell me how does HYPERVENTILATION helps in protection against brain damage??
thank u,
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| lucky_doc
Forum Junior
Topics: 18
Posts: 45
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Hyperventilation is no longer recommended as a prophylactic intervention during the first 24 h after a severe traumatic brain injury. Nor is hyperventilation below a PaO2 of 25 mm Hg ever indicated. Hyperventilation does reduce the ICP, but the vasoconstriction caused by reducing carbon dioxide (CO2) levels also leads to cerebral ischemia. Hyperventilation is still used as a last resort for hospitalized patients with signs of increasing ICP despite other therapeutic measures. In this case it is a temporary measure and the PaO2 is monitored closely to maintain the range of 30 to 35 mm Hg!!!! HOPE this helps
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| arlete
Intern in 2009!!!!!
Topics: 30
Posts: 2,230
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lucky_doc you are sooooo handsome!
LOL! 
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When men make the rules, God decides the exceptions.
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| neurom
Forum Senior
Topics: 2
Posts: 127
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Hyperventilation does decrease coronary blood flow -->reduce ICP. It is used for patients with transtentorial herniation
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"Nature magically suits a man to his fortunes, by making them the fruit of his character".
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| neurom
Forum Senior
Topics: 2
Posts: 127
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correct myself: *cerebral blood flow
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"Nature magically suits a man to his fortunes, by making them the fruit of his character".
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| farnsworth
Forum Newbie
Topics: 0
Posts: 165
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lucky_doc is right: hyperventilation does not help in minimizing the extent of damage in traumatic brain injury!
2006 in Intensive Care Medicine:
The "Lund Concept" for the treatment of severe head trauma--physiological principles and clinical application.
Grände PO.
University Hospital of Lund, Department of Anaesthesiology and Intensive Care, SE-221 85 Lund, Sweden. per-olof.grande@med.lu.se
The Lund Concept is an approach to the treatment of severe brain trauma that is mainly based on hypotheses originating from basic physiological principles regarding brain volume and cerebral perfusion regulation. Its main attributes have found support in experimental and clinical studies. This review explains the principles of the Lund Concept and is intended to serve as the current guide for its clinical application. The therapy has two main goals: (1) to reduce or prevent an increase in ICP (ICP-targeted goal) and (2) to improve perfusion and oxygenation around contusions (perfusion-targeted goal). The Lund therapy considers the consequences of a disrupted blood-brain barrier for development of brain oedema and the specific consequences of a rigid dura/cranium for general cerebral haemodynamics. It calls attention to the importance of improving perfusion and oxygenation of the injured areas of the brain. This is achieved by normal blood oxygenation, by maintaining normovolaemia with normal haematocrit and plasma protein concentrations, and by antagonizing vasoconstriction through reduction of catecholamine concentration in plasma and sympathetic discharge (minimizing stress and by refraining from vasoconstrictors and active cooling). The therapeutic measures mean normalization of all essential haemodynamic parameters (blood pressure, plasma oncotic pressure, plasma and erythrocyte volumes, PaO(2), PaCO(2)) the use of enteral nutrition, and avoidance of overnutrition. To date, clinical outcome studies using the Lund Concept have shown favourable results.
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| drduck
Forum Guru
Topics: 82
Posts: 529
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thanks all,
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