60 yr old.

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60 yr old.

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SILVER
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01/21/08 - 09:44 AM

A 60 yr. old man with angina comes to the ER with severe chest pain unresponsive to sublingual nitroglycerin. EKG shows ST segment elevation in the anterolateral leads, and thrombolytic therapy is initiated. If streptokinase is given to this patient, it may produce thrombolysis after binding to which of the following?

A. Antithrombin III
B. Fibrin
C. Plasminogen
D. Protein C
E. Thrombomodulin

Give your reasoning!

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new_n_lost
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01/21/08 - 09:53 AM

C. Plasminogen >> that the MOA of Streptokinase it binds with plasminogen and catalyzes the reaction to Plasmin.

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Tiff
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01/21/08 - 11:21 AM

C.

b/c streptokinase binds plasminogen and ehances it's conversion to plasmin

fluoxetin
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01/22/08 - 03:16 PM

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01/23/08 - 08:58 AM

new_n_lost wrote:
C. Plasminogen >> that the MOA of Streptokinase it binds with plasminogen and catalyzes the reaction to Plasmin.

yes! the question is basically testing your knowledge about the mechanism of action of streptokinase.

Easy one!

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