usmlesavvy
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Q.1.A 3 year old child has been admitted to the ER.Anti muscarinic drug overdose is suspected.In very young children , the most dangerous effect of Belladonna alkaloids is:
a.Dehydration
b.Hallucination
c.Hypertention
d.Hyperthermia
e.Intraventricular heart block
Edited by usmlesavvy on 01/20/08 - 12:16 PM
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| usmlesavvy
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Q.2. When a moderate pressor dose of norepinephrine is given after pretreatment with a large dose of atropine ,which of the following is the most probable response to norepinephrine?
a.A decrease in heart rate caused by direct cardiac effect
b.A decrease in heart rate caused by indirect reflex effect
c.An increase in heart rate caused by direct cardiac action
d.An increase in heart rate caused by indirect reflex action
e.No change in heart rate
Edited by usmlesavvy on 01/20/08 - 12:17 PM
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| new_n_lost
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Can you please un bold the font and write them in a normal fashion like you are here for a long time and you do know the standards of posting dont you ???
Please reformat your questions
Thank you.
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| usmlesavvy
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Oops...sorry NNL...here Qs re- formated!
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| new_n_lost
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usmlesavvy wrote:Oops...sorry NNL...here Qs re- formated!
Thank you
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| new_n_lost
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Q.1. d.Hyperthermia
Q.2. c.An increase in heart rate caused by direct cardiac action >> the normal reflex action of bradycardia by Nor epi thru the baroreceptor reflex will be countered by Atropine blocking the vagal response of baroreceptors. Thus producing Tachycardia. One should also remember that a large dose of Atropine itself produces tachycardia by blocking the M2 receptors at heart.
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| Tiff
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#1 - d - Hyperthermia
#2 - c - increased HR by direct cardiac action. (increased HR via M2 antagonism in heart by atropine, and increased HR via beta-1 receptors in heart by norepinephrine)
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| usmlesavvy
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.1.d
Choices b,d,e , all are possible effects of Atropine group.In small children however the most dangerous effect is however HYPERTHERMIA.Deaths in excess of 42oC have occurred after use of atropine containing eye drops in children.
.2.c
Atropine will prevent the normal reflex bradycardia,since that requires the integrity of vagal path,way.Direct effact of NE on the sinus node will be unmasked!
Also,TACHY with a dose of Atropine itself is due to SANS predominance on the SA Node.(Atropine being a blocker will have zero efficacy)
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| usmlesavvy
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Q.3.A new drug was given by subcutaneous injection to 25 normal subjects in a phase 1 clinical trial.The CVS effects are summarized below.Which of the following drug does the new drug most resemble?
VARIABLE-------------------------- CONTROL----------------- PEAK DRUG EFFECT
SystolicBP(mmHg)------------------- 116 ---------------------------- 144
DiastolicBP(mmHg)--------------------76 ------------------------------ 96
Cardiac Output(L/min)---------------- 5.4 ---------------------------- 4.7
Heart Rate(beats/min)--------------- 71.2 --------------------------- 54.4
a.Bethanechol
b.Epinephrine
c.Isoproterenol
d.Phenylephrine
e.Physostigmine
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| Tiff
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D. Phenylephrine - alpha1 agonist with reflex bradycardia
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| new_n_lost
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d.Phenylephrine
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