kirvam
Forum Newbie
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Posts: 2
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Q)which of the following modifications of an endogeneous pharmacologically active peptidewould be most likely to slow the metabolism of the peptide thus decreasing its clearance and increasing its half life?
A)decreasing the number of amino acids in the peptide
B)substituting a D for an L amino acid
C)ensuring a free amino group at the N terminal
D)ensuring a free carboxyl group at the C terminal
E)administering the peptide with an enteric coating
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| Tiff
Forum Guru
Topics: 54
Posts: 561
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Choice B.
Think it forms an enzyme resistant derivative since L is more abundant than D.
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