asmi
Forum Hero
Topics: 1043
Posts: 4,609
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pt on antineoplastics..,gout ,pt on thiazide ,loop diuretics .
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| crista
Forum Guru
Topics: 121
Posts: 408
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high fructose diet
aldolase Bdef.
von gierke dis.
glucose 6 phosphate dehydrogenase def.
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| monsieur_76
Forum Newbie
Topics: 9
Posts: 22
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Is it G6PD or glucose 6 phospatase deficiency.
I think it is the later.Havent come across the former.
Could you clarify.
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| monsieur_76
Forum Newbie
Topics: 9
Posts: 22
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I apologize you mentioned the glucose 6 phosphatase already-(Von Gierke).
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Would someone explain why G6PD-deficiency would give you hyperuricemia.
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| Colombia
Forum Guru
Topics: 85
Posts: 438
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anti TB drugs= Ethambutol,pyrazanimide
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| anne
Forum Elite
Topics: 41
Posts: 348
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hi colombia,are u sure of ethambutol having hyperuricemia as side effect.as far as i know,pyrazinamide causes hyperuricemia.ethambutol causes retrobulbar neuritis and red-green color blindness.do correct me if i am wrong.
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| Colombia
Forum Guru
Topics: 85
Posts: 438
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Hi Anne! Ethambutol produces gout (Lippicott's p.335)
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Please remember: hyperuricemia does not cause gout. Many people can be hyperuricemic and not have gout, and vice versa.
and anyone who can tell me why G6PD-deficiency causes gout gets a gold star.
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| peekay
Forum Guru
Topics: 102
Posts: 588
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you are activating pentose phosphate shunt and hence increase in PO4 .
PO4 ----->increased PRPP ----->Increases Purine synthesis
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| anne
Forum Elite
Topics: 41
Posts: 348
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thanx columbia and all!!
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| m & m's
Forum Newbie
Topics: 0
Posts: 1
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This response comes a little late, but maybe it can help someone else.
G6PD is necessary in RBC's to produce NADPH which in turn is needed for antioxidant function in the cell. G6PD deficiency causes hemolysis, uric acid is released and can cause gout.
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| docofthebigapple
Forum Senior
Topics: 23
Posts: 174
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Would someone please shed some more light on how G6PD deficiency contributes towards Gout/Hyperuricemia? I fail to understand the point here.
My questions are
1. Is uric acid released from the RBCs?
2. Are there any precursors/intermediates of the purines in the RBCs that lead to uric acid production.
I'm sure some one will answer me.
Thanks
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| mjl1717
Forum Hero
Topics: 955
Posts: 5,450
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Doc of big apple--He didnt shed ANY light on uric acid./G6PD.
Unless hes saying: G6PD causing Hemolysis :arrow:
Hemolysis :arrow: excess purines from DNA structural disturbance
:arrow: uric acid from excess purine catabolism??????????????
Can anyone answer this????????
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| slim
Forum Newbie
Topics: 2
Posts: 4
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G6P deficiency → build up of G6P → stimulates 6MP shunt → more ribo 5P product → more substrate for nucleotide synthesis → more purines to break down → hyperuricemia
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,796
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whtz 6MP shunt?
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| slim
Forum Newbie
Topics: 2
Posts: 4
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sorry; hexose monophosphate shunt. so with G6Pase deficiency, you can't dephosphorylate your G6P to get it out out of the liver (for gluconeogenesis). so it takes the path of least resistance and goes to the hexose monophosphate shunt (it's the beginning substrate here).
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,796
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hye buddy i get ur point ,in VONgierke's disease there will be hyperurecimia by the mech. u mentioned but also because of PO4-- trap and lactic acidosis which prevents uric acid excretion!
but as few ppl mentiond here abt G6PDH def. i don't understand how it will lead to hyperricemia!
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| mjl1717
Forum Hero
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In the end: The most common cause of congenital hyperuricemia is HGPRT def. The most common cause of adult hyperuricemia is dehydration.
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| 99doc
Forum Elite
Topics: 52
Posts: 370
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in G6phosphatedef. ,phophyraled sugars acumulate,decreasing the available Pi& increasing the AMP,LEADING TO HYPERURICEMIA.
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