crista
Forum Guru
Topics: 121
Posts: 408
|
what is the most common? def of pyruvate kinase or glucoso6phosphate?
how could you differentiated between?
|
| anne
Forum Elite
Topics: 41
Posts: 348
|
i guess G6PD def is commonest,and we may differentiate between the two by presence of heinz bodies in G6PD def.
|
| peekay
Forum Guru
Topics: 102
Posts: 588
|
pyruvate kinase is the most common glycolytic pathway def.
P.K increase in 2,3 BPG and hence shifting of O2 curve to tright.
G6PD = history must say exposure it oxidizing agents. and heinz bodies on smear review. ( if i may suggest every one should know about how it looks)
enzyme essays for both are diagnostic
|
| crista
Forum Guru
Topics: 121
Posts: 408
|
thank you.
|
| piter
Forum Elite
Topics: 34
Posts: 191
|
also G6PD X-linked and self limited, PK is chronic and sustained.
|
| crista
Forum Guru
Topics: 121
Posts: 408
|
G6PD is not so self limited if you think about type I with enzyme activity below 2%...
|
| piter
Forum Elite
Topics: 34
Posts: 191
|
yes, in rare cases, mutation may decrease the activity of G6PDH to cause chronic nonsherocytic hemolitic anemia. Symptoms of cronic granulomatous disease may develop if G6PDH below 5%, also rare, but that's different d-ses.
from kaplan, brs.
|
|
| |
| | | | | | | |
