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Kaplan Qbank USMLE



Author80 Posts
  #26

Proline and Lysine residues of collagen are hydroxylated by proline hydroxylase and lysine hydroxylase right after synthesis and this modification is for proper connective tissue function of Collagen. These 2 enzymes require 4 cofactors; Fe++, O2, Vit C & alpha-ketoglutarate. So I'd say; "Keep Our Collagen Fine" to memorize these molecules :wink:
Just to remind; Lysine Hydroxylase gene is mutated in Ehlers Danlos, also know as "Ehlers Danlys" smiling face :arrow: hyperelasticity and fragility of the skin, hypermobility of the joints, and fragility of the cutaneous blood vessels, etc.

  #27

ToMYs GirlFrind is AHa!!

TRINUCLEOTIDE REPEAT DISORDERS:
everywhere it is repeat of C__G , where __ stands for:

T(CTG) : in Myotonia dystrophica

G(CGG): in FRagile x syndrome

A(CAG) : Hungtons chorea and other disorder


ToMYs GirlFrind is AHa!!


ny new improvements r always welcome.

  #28

I need to memorize the structures (not just the hydrophobicity, esstential, etc, I need to be able to draw them).

Anyone know any good tricks to memorizing the structures for all 20 amino acids?

Thanks!

  #29

How do you link freckles, Thymine-Thymine dimers, and UV light?

Think of Peppermint PaT-Ty (freckles) taking a UV light bath. 8)

___________________
Ricardo
Life is what happens to you while you're busy making other plans. (Lennon)

  #30

Essential amino acids; The Life ARGentina’s Maradona LEd IS TRYP, HIStorical, PHYlosphical, VALorous

  #31

Do Enter After the Bell

Cyclin D/E - G1 :arrow: S
Cyclin A - S :arrow: G2
Cyclin B - G2 :arrow: M

___________________
life is guud

  #32

For Eukaryotic Cells- DNA Replication

U all probably already thought of this but just wanted to put it down for my satisfaction: THANX!!

LeaDing strand- dna polymerase Delta

LA[/color ]gging strand- dna polymerase [color=#cc0000]Alpha


  #33

Let me repeat the last part of that one again:

LAgging Strand- dna polymerase Alpha


  #34

I always forget competitive and non-competitive inhibition on linewiever burk graph.so i made this.

in competitive inhibtion there is always competetion between two lines so they cross on graph.So solute concentration chages but velocity remains same.vice versa for non competitive.

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Can't think of a nice sig right now...

  #35

km always higher than vmax like either km inc and vmax same or km same vmax dec

kmpitative inhibitor ==km
increase ,vmax same

non kmpitative inhibitor==== km not increased, vmax decreased


Edited by drkaur on 09/18/05 - 11:35 AM

  #36

drstepbystep wrote:

How do you link freckles, Thymine-Thymine dimers, and UV light?

Think of Peppermint PaT-Ty (freckles) taking a UV light bath. 8)

what is this for?in regards to what?ciould you clarify?








  #37

FORMULA FOR ATPs DERIVED FROM OXIDATION OF FATTY ACIDS

n=number of carbons , N=n/2

ATP=(12xN) + (5x(N-1)) -2






  #38

Learning the Cofactors for Enzymes is Painful so you hit them with a BAP!
BAP! Tender Loving Care for Noone!

(BAP needs TLCFN)

Branched Chain Ketoacid DH
Alpha ketoglutarage DH
PDH
(by the way, all are DH enzymes; ALL DH enzymes produce NADH)

they need:

TTP from Thiamine (B1)
Lipoic Acid (Synthesized; not from a vitamin)
CoA (from Pantothenate)
FAD(H2) from Riboflavin (B2)
NAD(H) from Niacin (B3)

To remember what TLCFN comes from its: BSPRN (bull sh.. prn)

grin


Another one:

Carboxylases need ABC:
ATP, Biotin, CO2

All Dehydrogenases: make NADH

All Kinases: Phosphorylate (KINdly put a phosphate on)

All Phosphatases: DEphosphorylate (PhosphaTASE, TAKES off Phosphate)

Glucagon puts Phosphate ON (phosphorylates); and INversely INsulin does the opposite (dephosphorylate)

This is a good way to remember what enzymes of which pathways are active/inactive in phosphorylated/dephosphorylated form

eg. Insulin activates Glycolysis, and Glycogen synthesis, so the enzymes that it activates in those pathways will be active in DEphosphorylated form.

and: Glucagon activates Glycogenolysis and Gluconeogenesis, so the enzymes that it activates in those pathways will be active in Phosphorylated form.





___________________
Our greatest glory is not in never falling, but in rising every time we fall.

  #39

A little tragic no one has taken up the Peppermint patty question.

My guess is it refers to Xeroderma pigmentosa, an autosomal recessive disorder of DNA repair. Humans typically utilize DNA excision repair, etc. to repair Thymidine dimers caused by exposure to UV light (UVB). There does exist another utilization to specifically fix these dimers called DNA photolyase, however if ever on a question this answer MUST be wrong since humans do not produce photolyase. Mutations in DNA excision repair mechanisms on the XP genes can cause build-up of thymidine dimers, which causes DNA damage, which of course leads to mutations and problems of expression. The end result is these patients have freckles, photosensitivity, and a propensity to have "paper-like skin". They also develop Basal and Squamous carcinomas and Actinic keratoses.

Mneumonic: Pepermint Patty, in a UV bath, with Windows XP.

  #40

PPG= Pyruvate, phosphofructo,gluco kinase= 3 irreversibile reaction in glycolysis.
Preaty Please Go!

___________________
When God is protecting who can stand against?May God be with all of us.

  #41

not a mnemonic but an observation:

all amino acids that start with T are ketogenic and glucogenic

threonine
tyrosine
tryptophan

all amino acids that start with A except arginine are non-essential

aspartate
alanine
asparagine




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It has been a looooong hard journey but I am inches away from my destination...

  #42

sis(CYS)ter THRew WATER MElon At SiR

cyst threoninie hydrophillic MEt Asp Ser

some one for the hydrophobic ones please


___________________
If you yourself are at peace, then there is at least some peace in the world.

  #43

shuttles related to lipids

SIT and synthesize...CITRATE -->synthesis

CAR burns Fuel ....CARnitine --> burning fat


___________________
If you yourself are at peace, then there is at least some peace in the world.

  #44

gene expression

what binds what?

oPERator-->rosserPER (REPressor)


Enhancer?

E goes with F So enhancer with Factor transcription

PromoteR --> Polymerasse Rna

I keep confusing these and this is the only silly way which helps.if anyone has better ideas PLEASE post


___________________
If you yourself are at peace, then there is at least some peace in the world.

  #45

eukaryotic RNA polymerase

RNA polymerase III-->tRNA

Three goes with T

mRNA--> choose m for Middle number

so RNA poly II--> mRNA

RNA poly ONE is the Real ONE

poly I--> rRNA




___________________
If you yourself are at peace, then there is at least some peace in the world.

  #46

CATy,S GAsP: GALG!

Cysteine
Aspartate
TYrosine
Serine

Glutamine
ASparaginase
Proline

Glutamine
ALanine
Glycine !


  #47

Mnemonic for Heme synthesis:
SUCks Going Abroad Passing UROPe to PROTect HEMEric Iron from Lead.

  #48

pneumonic for glycogen storage disorders
Very Psychotic Child Admitted to Mental Hospital.
Vongierke's,Pompe's,Cori's,Andersen's,Mcardle's,Her&# 39;s

___________________
Dont worry.Nobody knows 100%

  #49

deficient enzyme in glycogen storage disoreder
A-B Anderson-(glycogen)Branching enzyme
C-D Cori's-(glycogen)Debranching enzyme
M-M Mcardle's-Muscle glycogen phosphorylase
H-H Her's-Hepatic glycogen phosphorylase

___________________
Dont worry.Nobody knows 100%

  #50

Hemophilia A is due to mutation in gene coding for clotting factor Aight and hemophilia B is a Bnine condition..Bnine stands for B that is Hemophilia B and nine is defective factor nine....







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