oddissy4u
Forum Guru
Topics: 107
Posts: 389
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MOA?
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| zeloc
Forum Junior
Topics: 11
Posts: 53
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Picrotoxin and bicuculline inhibit the GABA a ion channel, thereby having the opposite effects of barbiturates and benzodiapezines, so they can cause seizures and convulsions.
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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Picrotoxin, also known as cocculin, is a poisonous crystaline plant alkaloid, first isolated by Boullay in 1812.
Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive antagonist of GABA A receptors. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has a stimulative effect.
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