MOA of HMG CoA

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MOA of HMG CoA

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hero
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01/03/08 - 08:38 PM

q: (all hmg related issues are heavily tested)

Therapy with an HMG-CoA reductase inhibitor (statin) lowers serum low-density lipoprotein (LDL) cholesterol concentration by increasing the number of LDL receptors on the cell surface.
This action is mediated by which one of the following?
A. Decreased intestinal absorption of cholesterol
B. Up-regulation of cholesterol ester transfer proteins
C. Up-regulation of lipoprotein lipase activity
D. Decreased intracellular cholesteryl concentration
E. Decreased serum triglyceride concentration

jean robert
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01/04/08 - 02:21 PM

D

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Idlehands
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01/04/08 - 02:37 PM

B. Gemfibrozil
D. Decreased intracellular cholesteryl concentration

new_n_lost
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01/06/08 - 07:03 PM

D. Decreased intracellular cholesteryl concentration

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Idlehands
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01/06/08 - 10:23 PM

Idlehands wrote:
D. Decreased intracellular cholesteryl concentration

Tiff
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01/13/08 - 02:24 PM

I don't believe that statins have any significant effect on cholesteryl esters, but it does have an effect on triglycerides.

I'll go with choice E.

seem.bh

01/15/08 - 11:28 AM

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