hero
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73. A 53-year-old woman presents because of frequent, increasingly severe hot flushes, daytime fatigue, loss of concentration, absent menses for the past 18 months, and dyspareunia. She is 160 cm (64 in) tall and weighs 67 kg (146 Ib). She does not smoke and exercises regularly. She has had regular negative mammograms. Her mother and maternal grandmother had osteoporosis and compression fractures. She has no family history of breast cancer, diabetes, or cardiovascular disease. The fasting plasma glucose level is 93 mg/dL, total cholesterol level is 210 mg/dL, and high-density lipoprotein cholesterol level is 57 mg/dL.
Which of the following is not indicated for management of this patients menopausal symptoms?
A. Raloxifene
B. Low-dose, short-term combination estrogen/progesterone therapy
C. Vaginal lubrication
D. Calcium and vitamin D
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| Ivonne
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A--------> can cause more hot flashes
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| bax
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A
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| DrVirgo
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| | 01/06/08 - 07:46 AM
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| #4 |
Ivonne wrote:A--------> can cause more hot flashes
yes, increases hot flashes and also may worsen vaginal dryness, so it may not be good for this postmenopausal woman, especially since she is already having hot flashes and dypareunia.
And just to add, Raloxifene also increases the risk of thromboembolism (so its Contraindicated if History of DVT)
However Raloxifene can LOWER LDL and Cholesterol !
Edited by DrVirgo on 01/06/08 - 07:52 AM
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| nany
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so what is Raloxifene used for exactly guys ?
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| sprint123
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| | 01/09/08 - 02:39 PM
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| #6 |
raloxifene can be used in adjuvant chemotherapy for breast cancer in postmenopausal women instead of tamoxifen , since it does not act on endometrium.
raloxifene can also be used in HRT for women with menopausal symptoms other han hot flashes as raloxifene doesn't cure this!
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| nany
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ah...I see,
thanx sprint123
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| Ivonne
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| | 01/21/08 - 03:02 PM
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| #8 |
SERM(selective estrogen receptor modulator) examples:
1.-Raloxifene
2.-Tamoxifen
They both do not decrease hot flashes, increase DVTs and thromboembolism but give all the benefits of estrogens without increassing the risk of breast cancer in fact tamoxifen can be used prophylactically in women with increased risk factors for breast cancer.
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