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11 Posts

hero
Forum Guru

Topics: 42
Posts: 557

01/03/08 - 03:38 PM

31. A 69-year-old woman is referred to you after she experienced a fracture of her right hip. She stated that she had lost two inches in height over the past 5 years, and radiographs of her spine demonstrated multiple thoracic compression fractures. Dual-energy x-ray absorptiometry demonstrated a T score of
-4.5 and a Z score of -2.5. A work-up for secondary causes of osteoporosis was unrevealing. In considering the therapeutic options for this woman, you wish to use a medication to treat this patients osteoporosis that will stimulate osteoblastic bone formation. Which of the following agents approved for the treatment and prevention of osteoporosis is anabolic for bone?
A. Teriparatide
B. Bisphosphonates
C. Estrogens
D. Raloxifene
E. Calcitonin

cool doctor
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Topics: 1
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01/03/08 - 03:57 PM

D is approved for tx and prevention

hero
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Topics: 42
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01/03/08 - 04:24 PM

cool doctor wrote:
D is approved for tx and prevention

all of them approved for tx and prevention

anastamosis
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Topics: 34
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01/03/08 - 04:26 PM

B.

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hero
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Topics: 42
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01/03/08 - 04:33 PM

anastamosis wrote:
B.

i afraid you'll be disappointed, but not this one

anastamosis
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01/03/08 - 04:50 PM

ANABOLIC for bone?
Should be A.

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Ivonne
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Topics: 58
Posts: 1,654

01/03/08 - 04:56 PM

I didn't know that teriparatide was approved also for prevention. i thought it was only for treatment, of course A is the most anabolic, inicially i picked b.

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hero
Forum Guru

Topics: 42
Posts: 557

01/03/08 - 06:40 PM

The correct answer is A

Multiple therapeutic options are available for osteoporosis. Both antiresorptive and anabolic agents have been shown to increase bone mass and reduce the risk of fracture. Given the severity of this woman’s osteoporosis and her increased fracture risk, treatment with an anabolic agent is a reasonable option.
Once-daily administration of teriparatide, recombinant human parathyroid hormone (1-34), stimulates new bone formation on bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity. Teriparatide improves both bone mass and strength. Bisphosphonates, estrogens, raloxifene, and calcitonin inhibit osteoclastic bone resorption, thus permitting a favorable balance in bone remodeling, improved bone mass and reduced fracture risk.

arlete
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Topics: 50
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01/04/08 - 11:04 AM

Good one!

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dr.wad
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Topics: 3
Posts: 350

01/05/08 - 10:08 AM

#10

yes .....actually i was shocked when i read that parathormone is used for osteoprosis.

i guess this is one of most interesting paradox in medicine .....it states that medicine is a science of FACTS and not LOGIC..

drduck
Forum Guru

Topics: 82
Posts: 523

01/06/08 - 06:09 AM

#11

BIG ONE........i really had no idea about this one....cool.
very well explained too.....
thanks

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