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Xanthoma

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Tiff
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01/03/08 - 10:25 AM

A 16 year old boy has bilateral Achilles tendon xanthomas. His father died of an acute MI at 32 years old. Which of the following biochemical defects is most likely responsible for the physical finding in this patient?

A - Decreased clearance of VLDL

B - Deficient levels of apolipoprotein C-II

C - Deficient levels of apolipoprotein E

D - Deficient levels of capillary lipoprotein lipase

E - Deficient levels of LDL receptors

angel23
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01/03/08 - 10:27 AM

E)deficient levels of LDL receptors

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Ivonne
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01/03/08 - 10:40 AM

tendinous xanthomas---------> type II a dyslipidemia---------->Deficient levels of LDL receptors--------> E

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jean robert
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01/03/08 - 06:01 PM

E

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SmokyWaters
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01/05/08 - 11:52 AM

eeeeeeeeeya dabba duuu

Tiff
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01/05/08 - 12:00 PM

The correct answer to the question I posted is E nod

(deficient levels of low-density lipoprotein receptors). Achilles tendon xanthomas are pathognomonic for familial hypercholesterolemia (type II hyperlipoproteinemia) which is inherited in an autosomal dominant fashion. Absent of defective LDL receptors lead to an increase in the level of serum cholesterol, which deposits in the tendon sheaths. Patients die at an early age of an acute myocardial infarcion or stroke.

new_n_lost
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01/06/08 - 07:23 PM

E - Deficient levels of LDL receptors

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