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Author9 Posts
  #1

A 21 yo M with no significant PMH presents to your office with blood in his urine and mucosal bleeding while washing his teeth. The patient c/o intermittent "ringing in his ears". He denies any drug or alcohol abuse. He has no family history of bleeding disorders. Petechia are noted in the oral cavitie, as is dried blood in his nostrils.

Labs: hematocrit: 32%, WBC: 8000 with 60% neutrophils, platelet count 13 000, PT: 13 seconds, PTT: 28 seconds, LDH: 1200U/L, elevated indirect bilirubin. Coombs' test is positive, abdominal examination is unremarkable and spherocytes in peripheral smear. What is the most likely diagnosis:

a. Alports' syndrome

b. Bernard-Soulier syndrome

c. Feltys' syndrome

d. Thrombotic thrombocytopenic purpura

e. Evans' syndrome

f. Idiophatic thrombocytopenic purpura

Explain your answer pz


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"Believe you can and you're half way there."

  #2

A...tinnitus makes me think of it..also being a collagen disorder it causes mucosal bleeding??

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Old McDonald had an ERAS inbox..with a reject here and a reject there..here a reject, there a reject,everywhere a reject, reject.

  #3

E. EVANS SYNDROME---Autoantibodies are directed against specific antigens specific to red cells, platelets, or neutrophils, but they do not cross react

Evans syndrome is a diagnosis of exclusion
Signs of thrombocytopenia include purpura, petechiae, and ecchymoses.
Signs of anemia include pallor, fatigue, and light-headedness.
Jaundice may indicate hemolysis

  #4

D? in Evans syndrome neutropenia should be present

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"Nature magically suits a man to his fortunes, by making them the fruit of his character".

  #5

EVAN's Syndrome = ITP + Autoimmune Hemolytic Anemia

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  #6

wats the answer ivonne

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  #7

Yeah Evan's is ITP + AIH
but I think I ll go w/ A, Alports bec of the pt's age, blood in urine & hearing prob.

  #8

The answer given is Evans' syndrome well explained in previous posts


___________________
"Believe you can and you're half way there."

  #9

what was the reason for intermittent ringing in the ears??









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