Tiff
Forum Guru
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The herpes simplex virus has many ways of avoiding the immune response. The HSV ICP47 protein can block the transfer of antigenic peptides from the cytoplasm to the endoplasmic reticulum of the infected cell. As a result of this action, which of the following immune responses is compromised?
A. Antibody production
B. CD4 T cell action
C. CD8 T cell action
D. Complement action
E. Interferon-alpha production
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| silver
Forum Guru
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C. CD8 T cell action
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| Tiff
Forum Guru
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That's correct!  C is the answer
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| new_n_lost
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C. CD8 T cell action
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| Tiff
Forum Guru
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Here's the explanation:
Antigenic peptide (8-9 amino acids) are transported from the cytoplasm to the ER so that they can bind to class I MHC molecules and be presented at the cell surface to CD8 T cells. Blocking this action inhibits antigen presentation, which then compromises the action of CD 8 T cells.
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| rado3105
Forum Newbie
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Yes C is right, proteins created by HSV bind to the lumen of TAP-molecules(TAP1, TAP2), that create channel to the endoplasmatic reticulum, what causes that peptides can´t get to the endoplasmatic reticulum and bind to the MHC and be presented to CD8(cytotoxic) lymphocytes.
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| macintosh
Forum Elite
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In other words it blocks the endogenous pathway of binding peptides to MHC class I molecules.
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