new_n_lost
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The presence of which of the following features in an atherosclerotic plaque indicates that it has become a complicated lesion?
A. Cholesterol crystals
B. Chronic inflammatory cells
C. Intimal smooth muscle
D. Lines of Zahn
E. Necrotic cell debris
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| GoodGirl
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 Lines of Zahn.
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| silver
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when plaque becomes disrupted thrombus develops--thrombi of heart have alternating red and pale areas known as lines of zahn ??
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| drgho
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D.
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| docdoc9
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d.Lines of zahn
When the plaque ruptures it can attract platelets and lead to formation of thrombi which have lines of zahn that is alternating pale and dark areas
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| new_n_lost
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silver wrote:
when plaque becomes disrupted thrombus develops--thrombi of heart have alternating red and pale areas known as lines of zahn ??
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| new_n_lost
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The correct answer is D.
Complicated lesions indicate advanced atherosclerotic disease. They arise in atherosclerotic plaques, and render them more susceptible to sudden occlusion and acute infarction of the supplied tissues. Commonly, the plaque ulcerates or ruptures, and the exposed surfaces, being highly thrombogenic, precipitate thrombus formation. Thrombi are typified by the lines of Zahn, alternating layers of platelets and fibrin (the pale lines) and layers of blood (the dark lines). Beyond thrombus formation, other features of a complicated plaque include hemorrhage into the lesion itself, and microembolism by cholesterol crystals or calcified debris. Furthermore, the weakened media underlying the plaque may develop an aneurysmal dilatation. In general, the clinical significance of atherosclerosis is related to the consequences of complicated lesions.
The incorrect options all include features of atheromatous plaques, but do not indicate complicated lesions:
Beneath the endothelium of a plaque there is a fibrous cap composed of smooth muscle (choice C), chronic inflammatory cells (choice B) and lipid laden macrophages (foam cells), as well as extracellular material.
The core of the lesion, which lies between the intima and the media, is composed of necrotic cellular debris (choice E), with cholesterol crystals (choice A), calcium, and more foam cells.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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