new_n_lost
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Examination, at autopsy, of the brain of a man who died in an intensive care unit demonstrates bilateral, linear, parasagittal areas of coagulative necrosis in the junctional zone between the anterior and medial cerebral arterial systems.
Which of the following is the most likely etiology?
A. Bacterial infection
B. Fungal infection
C. Ischemia
D. Tumor
E. Viral infection
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| GoodGirl
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What, what are you asking ??????
C
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| jean robert
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D??
Radiation of brain for tumor can give coagulation necrosis??
Curiously ischemia in the brain produces liquefactive rather than coagulative necrosis, this is due to the lack of any substantial supportive stroma.
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| GoodGirl
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Bilateral lesion ?
In junctional areas = watershed areas ?
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| silver
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where do you find these questions!! 
D. Tumor
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| new_n_lost
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GoodGirl wrote:What, what are you asking ?????? C
See you still get the answer.............
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| new_n_lost
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The correct answer is C.
The distinctive areas of necrosis described in the question stem are border zone (watershed) infarcts. They occur as the result of severe ischemia, which most profoundly affects the relatively poorly perfused areas at the boundaries between major arterial territories. The areas of necrosis described in the question stem are those most commonly observed, although similar infarcts involving border zones in the brain stem are sometimes also seen.
Bacterial infection (choice A) tends to produce either meningitis, cerebritis, or localized infections such abscesses.
Fungal infection (choice B) tends to produce either meningitis, vasculitis, granulomas, or abscesses.
Tumor (choice D) tends to produce localized masses.
Viral infection (choice E) may have a variety of patterns, including meningitis, diffuse encephalitis, or localized necrosis, but would not be expected to produce a distinctive linear pattern.
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| angel23
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does ischaemia produce coagulative necrosis in brain?
it produces liquefactive necrosis?????
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| silver
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angel23 wrote:does ischaemia produce coagulative necrosis in brain? it produces liquefactive necrosis?????
yeah, i had the same issue with this question. brain can only have liquefactive necrosis because the macrophages can't make collagen. now in this question if brain is undergoing coagulative necrosis, then radiation for a tumor makes sense to cause this. (Goljan p.15 & 16)
i don't know...still confused a bit about this ques and the expln. 
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| angel23
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yeah u r right
it shud b tumour................
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