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NNL Awaitin The Unexpected Topics: 779 Posts: 6613	Dec 17, 2007 - 2:19 PM       #1 Which of the following antihistamines would be the most appropriate treatment for an airline pilot with hay fever? A. Chlorpheniramine B. Diphenhydramine C. Meclizine D. Pyrilamine E. Terfenadine
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hope4dabest Forum Guru Topics: 23 Posts: 456	Dec 17, 2007 - 10:12 PM       #2 cannot be 1st three choices..has to be some less sedating 2nd generation....Dont know abt choice D and E
hero Forum Guru Topics: 67 Posts: 950	Dec 17, 2007 - 10:38 PM       #3 C if he also has motion sickness. Chlorpheniramine can cause paradoxal CNS stimulation - it might work Not Terfenadine - risk of cardiac arrhythmias. Not B and D bcs of sedation Must be Loratadine or Fexofenadine as a choice for the pilot
drpswathi Forum Newbie Topics: 1 Posts: 16	Dec 18, 2007 - 9:37 AM       #4 E - TERFINADINE- good for short term & intermittent use. its carboxymetabolite produces torsades de pointes only with overdose. wat is the correct answer?
PGI2alpha Forum Elite Topics: 7 Posts: 446	Dec 18, 2007 - 10:18 AM       #5 E...least drowsiness among all of the above
SILVER DoWhatYouGotToDo! Topics: 56 Posts: 1289	Dec 18, 2007 - 10:21 AM       #6 E
hero Forum Guru Topics: 67 Posts: 950	Dec 18, 2007 - 3:32 PM       #7 When in Rome do as the Romans do. http://www.fda.gov/bbs/topics/ANSWERS/ANS00853.html currently E can not be right answer on USmle
NNL Awaitin The Unexpected Topics: 779 Posts: 6613	Dec 18, 2007 - 3:34 PM       #8 PGI2alpha wrote: E...least drowsiness among all of the above
NNL Awaitin The Unexpected Topics: 779 Posts: 6613	Dec 18, 2007 - 3:36 PM       #9 The correct answer is E. Terfenadine is the only drug listed that does not cross the blood-brain barrier and therefore does not cause sedation (a bad thing for someone flying an airplane). Other drugs from the same class (piperidines) include astemizole and loratadine. All of the other choices have some degree of sedation as a side effect and therefore would not be recommended for someone who is flying an airplane or operating any kind of machinery.

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