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Kaplan Qbank USMLE



Author6 Posts
  #1

The oncogene associated with small cell CA of the lung is?

A. N-myc

B. erb-2

C. ret

D. L-myc

E. bcl-2

  #2

N-myc?


  #3

D, l-myc

remember, PGI2alpha, L is for Lung is for L-myc, ok? smiling face


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  #4

Oncogenes: Amplification of the myc family of oncogenes is the most common molecular abnormality identified in SCLC cell lines, xenografts in nude mice, and fresh tumor specimens. This change, however, is not identified in all SCLC tumors. Therefore, myc expression is unlikely to be an initial event in the pathogenesis of SCLC. C-myc, a member of the myc family, is found more commonly in relapsed tumors than in untreated tumors, and its expression in SCLC may carry a worse prognosis.

Other members of the myc oncogene family include N-myc and L-myc, which have been found to be amplified in SCLC. N-myc amplification in SCLC also has been associated with resistance to therapy and poorer prognosis. Overall, the exact role of amplification of the myc family of oncogenes in the pathogenesis of SCLC is not clearly understood at present and requires further study.

Rest of the Article here

And this is exactly what Robbins also says. I have the Pocket version of 6th edition, if anyone can look it up in the new Edition it would be great.


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  #5

yes! the correct answer is L-myc!

  #6

L-myc........nodnodnod

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