gag_pol_env
Forum Newbie
Topics: 3
Posts: 10
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Can anyone tell that why acetyl CoA formed from FA,s cannot be converted to glucose in citric acid cycle.Is there any reason to it or we just need to remember it.Why it does not exit at Malate?
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| GoodGirl
Forum Guru
Topics: 102
Posts: 1,395
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I think it can, but main pathway of FA beta oxidation, is to generate energy trough TCA and ETC , that is reason why FA are broken down, and not to bild glucose.
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| usmlesavvy
Forum Senior
Topics: 6
Posts: 187
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Hey gag_pol_env,
We cannot convert ACETYL-COA into Glucose becoz, the PDH(PYRUATE DEHYDROGENASE) STEP is IRREVERSIBLE......i.e we cannot convert Acetyl-coA back to pyruvate!
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| usmlesavvy
Forum Senior
Topics: 6
Posts: 187
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Well, I think you are pointing out to the fact that Intermediate of TCA CYCLE, i.e MALATE is Gluconeogenic, so why cant ACETYL-COA form glucose via TCA thru MALATE........? But dont forget that in TCA cycle,ACETYL-COA is converted to CO2.
Theres no NET formation of any of the intermediates,nor are the used up.So there will be no NET formation of Glucose from Acetly-coA if Malate feeds into Gluconeogenesis pathway.
hope that helps
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How can you hesitate?Risk!Risk anything!care no more for the opinion of others,for those voices.Do the hardest thing on earth for you.Act for yourself.Face the truth.....
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| SmokyWaters
Forum Elite
Topics: 6
Posts: 447
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when we get the net reaction of the citric acid cycle..
the number of carbons are balanced except 2 carbons...which are contributed by acetyl Co A...
these 2 carbon atoms are removed in the form of CO2
so that why we say that acetyl CoA cannot be converted to glucose
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