hope4dabest
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In kaplan its given that " STIMULI THAT PROMOTE INSULIN SECRETION--GLUCAGON".
And then later on they say " GLUCAGON INHIBITS RESPONCE TO INSULIN"
Aren't these 2 contraindicatory statements...Somebody clear this doubt
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| GOGETA
I'm Dr. GOGETA
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both are correct
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| hope4dabest
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If u could explain more?
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| new_n_lost
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In essence what they are trying to say that there is a balance proportion of glucagon and insulin in the body at the same time normally refered to as the Insulin -glucagon ratio.
If there is increased concerntration of Glucagon in the body it will lead to a secretion of Insulin.
Glucagon is an gluconeogenic hormone so when released leads to mobilization of AA and thus glucose to drive in this glucose the insulin is released in response to hyperglycemia. As the B cells in pancreas release Insulin they also release GABA and GABA inhibits the A cells and which in turn stop Glucagon production.
Glucagon causes hyperglycemia while Insulin causes hypoglycemia. Now we do know that in state of hyperglycemia Insulin is released and hypoglycemia Glucagon is released. Thus these 2 enzymes in a way regulate each other.
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| hope4dabest
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ok..so they balance each other...Thanks NNL
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| SmokyWaters
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actually glucagon secreting cells are in periphery and insulin secreting in center of islets of langerhans...the blood flow is from center to periphery...
when insulin is stimulated .. it inhibits glucagon....
but when glucagon comes from behind.. it can stimulate insulin...
as for the reactions occuring in the body...insulin/glucagon ratio is workin ...
one more thing... insulin is released in a pulse when there is high glucose levels...then there is continuous release ..the PULSE inhibits glucagon first ... I dunno if you got it or not :S
I mean there is no interference simply said...
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