philadelphia chromosome?

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philadelphia chromosome?

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uncle SAM watin
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Topics: 12
Posts: 24

12/06/07 - 12:07 AM

Hi,i m bit confused,if there occurs reciprocal translocation in CML between chromosome 9 n 22,as per KLN in ds type of translocation a part of long arm of chromosome 9 n 22 is exchanged.My question z wch of two recombinat choromosomes is so called PHILADELPHIA CHOROMOSOME,9 OR 12.

new_n_lost
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12/06/07 - 08:49 AM

CML is an acquired abnormality that involves the hematopoietic stem cell. It is characterized by a cytogenetic aberration consisting of a reciprocal translocation between the long arms of chromosomes 22 and 9; t(9;22). The translocation results in a shortened chromosome 22, an observation first described by Nowell and Hungerford and subsequently termed the Philadelphia (Ph) chromosome after the city of discovery.
This translocation relocates an oncogene called abl from the long arm of chromosome 9 to the long arm of chromosome 22 in the BCR region. The resulting BCR/ABL fusion gene encodes a chimeric protein with strong tyrosine kinase activity.

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uncle SAM watin
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Topics: 12
Posts: 24

12/07/07 - 12:29 AM

Atually ds concept i know,bt my question z where does part of chrmosome 9 translocate .According to concept of reciprocal translocation there z exchange of part of chromosomes between two non homologous chromosomes dtz for CML a part of long arm of ch22 translocates to ch 9 ok,where does part of ch 9 translocate accoding to reciprocal translocation to ch22, how come it z shortened.

new_n_lost
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12/09/07 - 05:01 PM

uncle SAM watin wrote:
Atually ds concept i know,bt my question z where does part of chrmosome 9 translocate .According to concept of reciprocal translocation there z exchange of part of chromosomes between two non homologous chromosomes dtz for CML a part of long arm of ch22 translocates to ch 9 ok,where does part of ch 9 translocate accoding to reciprocal translocation to ch22, how come it z shortened.

Can you please elaborate on the words highlighted and care to repost the your question because i simply cant understand it..
Thank you.

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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

hope4dabest
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Topics: 15
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12/09/07 - 05:32 PM

ds--this
z--is
bt--but
dtz--that is
not sure abt dtz grin

new_n_lost
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12/09/07 - 08:14 PM

hope4dabest wrote:
ds--this
z--is
bt--but
dtz--that is
not sure abt dtz

If thats the translation then i refuse to answer a person who doesnt bother to write complete English because it pisses me off. mad

___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

uncle SAM watin
Forum Newbie

Topics: 12
Posts: 24

12/12/07 - 02:54 AM

I m sory,actually i m new to this form,hope u answer my question.

uncle SAM watin
Forum Newbie

Topics: 12
Posts: 24

12/12/07 - 02:57 AM

Translation
ds- this
z- is
dt -that
dtz- that is

lakshya_0_7
Forum Elite

Topics: 19
Posts: 240

02/17/08 - 02:16 AM

chromosome 22 is called the "philadelphia chromosome"....

New_n_lost - you got a "n" in your name too.. disapproval

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